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The Innovation Life > 2025 Vol. 3 > No. 4 > 100160
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Cartilage-targeted drug delivery in osteoarthritis: Redefining local therapy with intelligent hydrogel microspheres

  • 1.

    Department of Biomedical Engineering, The Chinese University of Hong Kong, NT, Hong Kong SAR 999077, China

  • 2.

    InnoHK Center for Neuromusculoskeletal Restorative Medicine, Hong Kong Science and Technology Park, Hong Kong SAR 999077, China

  • 3.

    Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

  • 4.

    Institute for Tissue Engineering and Regenerative Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, NT, Hong Kong SAR 999077, China

  • 5.

    Peter Hung Pain Research Institute, Faculty of Medicine, The Chinese University of Hong Kong, NT, Hong Kong SAR 999077, China

  • 6.

    These authors contributed equally to this work

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The Innovation Life  3(4),  https://doi.org/10.59717/j.xinn-life.2025.100160  |  Cite this article
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    • REFERENCES
  • [1] Glyn-Jones S., Palmer A.J., Agricola R., et al. (2015). Osteoarthritis. Lancet 386:376−387. DOI:10.1016/s0140-6736(14)60802-3

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    [2] Sophia Fox A. J., Bedi A., and Rodeo S. A. (2009). The basic science of articular cartilage: Structure, composition, and function. Sports Health 6:461−468. DOI:10.1177/1941738109350438

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    [3] Lu Y., Liu Y., Xia X., et al. (2025). Trojan horse-inspired spatiotemporal strategy augments cartilage regeneration by enhancing mitochondrial energy production. The Innovation 6:100913. DOI:10.1016/j.xinn.2025.100913

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    [4] Lei Y., Wang Y., Shen J., et al. (2022). Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis. Sci. Adv. 8:eabl6449. DOI:10.1126/sciadv.abl6449

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    [5] Liu J., Liu J., Liu S., et al. (2025). Cascade targeting selenium nanoparticles-loaded hydrogel microspheres for multifaceted antioxidant defense in osteoarthritis. Biomaterials 318:123195. DOI:10.1016/j.biomaterials.2025.123195

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  • Cite this article:

    Liu J., Liu S., Du C., et al. (2025). Cartilage-targeted drug delivery in osteoarthritis: Redefining local therapy with intelligent hydrogel microspheres. The Innovation Life 3:100160. https://doi.org/10.59717/j.xinn-life.2025.100160
    Liu J., Liu S., Du C., et al. (2025). Cartilage-targeted drug delivery in osteoarthritis: Redefining local therapy with intelligent hydrogel microspheres. The Innovation Life 3:100160. https://doi.org/10.59717/j.xinn-life.2025.100160

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