Engineering bacterial biocatalysts via directed evolution to deprive cancer cells of cyst(e)ine
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REFERENCES
[1] Forbes N.S. (2010). Engineering the perfect (bacterial) cancer therapy. Nat. Rev. Cancer 10:785−794. DOI:10.1038/nrc2934 [2] Sznol M., Lin S.L., Bermudes D., et al. (2000). Use of preferentially replicating bacteria for the treatment of cancer. J Clin. Invest. 105:1027−1030. DOI:10.1172/JCI9818 [3] Wang Y.Z., Chen W.H., Han Z.Y., et al. (2025). Targeted tumor therapy with L-cyst(e)ine-addicted bacteria-nanodrug biohybrids. Cell Metab. 37:1277−1293. DOI:10.1016/j.cmet.2025.03.012 [4] Li Y., Li Z., Sun D., et al. (2024). Adaptation to cystine limitation stress promotes PDAC tumor growth and metastasis through translational upregulation of OxPPP. bioRxiv. DOI:10.1101/2024.12.12.628246 [5] Dixon S.J., Patel D.N., Welsch M., et al. (2014). Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife 3:e02523. DOI:10.7554/eLife.02523 -
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Li Y., Li Q., Tan M., et al. (2026). Engineering bacterial biocatalysts via directed evolution to deprive cancer cells of cyst(e)ine. The Innovation Life 4:100189. https://doi.org/10.59717/j.xinn-life.2026.100189
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Li Y., Li Q., Tan M., et al. (2026). Engineering bacterial biocatalysts via directed evolution to deprive cancer cells of cyst(e)ine. The Innovation Life 4:100189. https://doi.org/10.59717/j.xinn-life.2026.100189
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Figure 1.
SFEc+ bacteria selectively target tumor tissues for cyst(e)ine deprivation
