Extraterrestrial bioconstruction technology system: Bridging space station applications and deep-space missions

Sheng Li; Yidong Gan; Cheng Zhou; Yan Zhou; Lieyun Ding

doi:10.59717/j.xinn-life.2026.100193

The Innovation Life > 2026 Vol. 4 > No. 1 > 100193

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Extraterrestrial bioconstruction technology system: Bridging space station applications and deep-space missions

1.
School of Civil and Hydraulic Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
2.
National Center of Technology Innovation for Digital Construction, Huazhong University of Science and Technology, Wuhan 430074, China
3.
These authors contributed equally

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Corresponding authors: chengzhou@hust.edu.cn (C.Z.); yanzhou@hust.edu.cn (Y.Z.)
Received Date: June 24, 2025

Accepted Date: January 08, 2026

Published Online: January 15, 2026

The Innovation Life 4(1), https://doi.org/10.59717/j.xinn-life.2026.100193 | Cite this article

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PUBLIC SUMMARY

PUBLIC SUMMARY
1. Microbe-driven bioconstruction offers a sustainable path for long-term human habitats in deep space.
  
  Systematically discusses the potential of microorganisms in extraterrestrial construction.
  
  Presents an 'Earth-Space Station-Extraterrestrial Object' multi-dimensional roadmap for bioconstruction.
  
  First proposes a full-lifecycle paradigm for extraterrestrial bioconstruction.

ABSTRACT

ABSTRACT

Microbe-driven bioconstruction offers a promising approach to sustainable deep-space habitats as missions shift from short-term exploration to long-term human presence. This review presents the first full-lifecycle bioconstruction paradigm that integrates Earth-derived extremophilic microorganisms, space station validation, and in-situ utilization of Lunar and Martian resources. It addresses gaps in extraterrestrial bioconstruction strategies. The proposed four-stage paradigm begins with biological pioneering using extremophilic microorganisms to establish survival conditions. This is followed by biological conversion of extraterrestrial resources for metal extraction, thereby enabling the synthesis of building materials through biological fabrication and their in-situ assembly into integrated habitats. The final stage involves integration into a self-sustaining life support system for long-term habitation. Key challenges include limited adaptability under compound space stresses, slow screening processes, limited in-orbit validation, and uncertain material longevity. Recommended directions include AI-driven strain optimization, expanded space and lunar experiments, and predictive modeling of material behaviour to support the development of resilient and resource-efficient extraterrestrial habitats.
- Extraterrestrial Bioconstruction, Bioengineering, Construction Paradigm, Microbial Metabolic Mechanisms /
- In-situ Resource Utilization

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REFERENCES

[1]	Pulsiri N., Dobson R.R., Isckia T., et al. (2022). Ad-Astra: A bibliometric analysis of Lunar and Mars explorations. 2022 Portland international conference on management of engineering and technology. IEEE. pp:1-8. DOI:10.23919/PICMET53225.2022.9882849 View in Article Google Scholar
[2]	Anand M., Crawford I.A, Balat-Pichelin M., et al. (2012). A brief review of chemical and mineralogical resources on the Moon and likely initial in situ resource utilization (ISRU) applications. Planet. Space Sci. 74:42−48. DOI:10.1016/j.pss.2012.08.012 View in Article CrossRef Google Scholar
[3]	Liu J., Li H., Sun L., et al. (2022). In-situ resources for infrastructure construction on Mars: A review. Int. J. Transp. Sci. Technol. 11:1−16. DOI:10.1016/j.ijtst.2021.02.001 View in Article CrossRef Google Scholar
[4]	Creech S., Guidi J., and Elburn D. (2022). Artemis: An overview of NASA's activities to return humans to the Moon. In 2022 IEEE aerospace conference (AERO). IEEE. pp:1-7. DOI:10.1109/AERO53065.2022.9843277 View in Article Google Scholar
[5]	Xu L., Li H., Pei Z., et al. (2022). A brief introduction to the international lunar research station program and the interstellar express mission. Chin. J. Space Sci. 42:511−513. DOI:10.11728/cjss2022.04.yg28 View in Article CrossRef Google Scholar
[6]	Amini K., Moradi M., Teymoori P.E.B., et al. (2022). Design of a set of habitat units and the corresponding surrounding cluster for long-term scientific missions in the pre-terraforming era on Mars. Icarus 385:115119. DOI:10.1016/j.icarus.2022.115119 View in Article CrossRef Google Scholar
[7]	Weppler J., Sabathier V. and Bander A. (2009). Costs of an international lunar base. Center for strategic and international studies. https://csis-website-prod.s3.amazonaws.com/s3fs-public/legacy_files/files/publication/090923_weppler_lunar_base_costs.pdf View in Article Google Scholar
[8]	Bao C., Zhang D., Wang Q., et al. (2024). Lunar in situ large-scale construction: Quantitative evaluation of regolith solidification techniques. Engineering 39:204−221. DOI:10.1016/j.eng.2024.03.004 View in Article CrossRef Google Scholar
[9]	Zhou C., Gao Y.Y., Zhou Y., et al. (2024). Properties and characteristics of regolith-based materials for extraterrestrial construction. Engineering 37:159−181. DOI:10.1016/j.eng.2023.11.019 View in Article CrossRef Google Scholar
[10]	Sakamoto K. and Wajima T. (2020). Preparation of geopolymer cement from simulated lunar rock sand using alkali fusion. Int. J. Geomate. 18:62−67. DOI:10.21660/2020.70.9162 View in Article CrossRef Google Scholar
[11]	Allende M.I., Miller J.E., Davis B.A., et al. (2020). Prediction of micrometeoroid damage to lunar construction materials using numerical modeling of hypervelocity impact events. Int. J. Impact Eng. 138:103499. DOI:10.1016/j.ijimpeng.2020.103499 View in Article CrossRef Google Scholar
[12]	Badyukov D.D. (2020). Micrometeoroids: The flux on the Moon and a source of volatiles. Solar Syst. Res. 54:263−274. DOI:10.1134/S0038094620040024 View in Article CrossRef Google Scholar
[13]	Seedhouse E. (2020). International space station life support system. Life support systems for humans in space (Springer Cham.), pp:151-179. DOI:10.1007/978-3-030-52859-1_5 View in Article Google Scholar
[14]	Liu H. (2025). Biogenic construction: The new era of civil engineering. Biogeotech. 3:100130. DOI:10.1016/j.bgtech.2024.100130 View in Article CrossRef Google Scholar
[15]	Berliner A.J., Lipsky I., Ho D., et al. (2022). Space bioprocess engineering on the horizon. Commun. Eng. 1:13. DOI:10.1038/s44172-022-00012-9 View in Article CrossRef Google Scholar
[16]	Nangle S.N., Wolfson M.Y., Hartsough L., et al. (2020). The case for biotech on Mars. Nat. Biotechnol. 38:401−407. DOI:10.1038/s41587-020-0485-4 View in Article CrossRef Google Scholar
[17]	Santomartino R., Averesch N.J.H., Bhuiyan M., et al. (2023). Toward sustainable space exploration: A roadmap for harnessing the power of microorganisms. Nat. Commun. 14:1391. DOI:10.1038/s41467-023-37070-2 View in Article CrossRef Google Scholar
[18]	Santomartino R., Zea L. and Cockell, C. S. (2022). The smallest space miners: Principles of space biomining. Extremophiles 26:7. DOI:10.1007/s00792-021-01253-w View in Article CrossRef Google Scholar
[19]	Dikshit R., Dey A., Gupta N., et al. (2021). Space bricks: From LSS to machinable structures via MICP. Ceram. Int. 47:14892−14898. DOI:10.1016/j.ceramint.2020.07.309 View in Article CrossRef Google Scholar
[20]	Sukhinov D.V., Gotovtsev P.M. and Sergeeva Y.E. (2023). Phototrophic microorganisms in bioregenerative life support systems for long-term crewed expeditions: Prospects and challenges. Acta Astronaut. 211:518−538. DOI:10.1016/j.actaastro.2023.07.006 View in Article CrossRef Google Scholar
[21]	Langenfeld N.J., Kusuma P., Wallentine T., et al. (2021). Optimizing nitrogen fixation and recycling for food production in regenerative life support systems. Front. Astron. Space. 8:699688. DOI:10.3389/fspas.2021.699688 View in Article CrossRef Google Scholar
[22]	Zhou X., Liang B., Zhang T., et al. (2024). Co-inoculation of fungi and desert cyanobacteria facilitates biological soil crust formation and soil fertility. Front. Microbiol. 15:1377732. DOI:10.3389/fmicb.2024.1377732 View in Article CrossRef Google Scholar
[23]	Shu W and Huang L (2022). Microbial diversity in extreme environments. Nat. Rev. Microbiol. 20: 219–235. DOI: 10.1038/s41579-021-00648-y. View in Article Google Scholar
[24]	Gostinčar C., Stajich J.E. and Gunde-Cimerman N. (2023). Extremophilic and extremotolerant fungi. Curr. Biol. 33:R752−R756. DOI:10.1016/j.cub.2023.06.011 View in Article CrossRef Google Scholar
[25]	Moroni L., Tabury K., Stenuit H., et al. (2022). What can biofabrication do for space and what can space do for biofabrication. Trends Biotechnol. 40:398−411. DOI:10.1016/j.tibtech.2021.08.008 View in Article CrossRef Google Scholar
[26]	Cockell C.S. (2022). Bridging the gap between microbial limits and extremes in space: Space microbial biotechnology in the next 15 years. Microb. Biotechnol. 15:29−41. DOI:10.1111/1751-7915.13927 View in Article CrossRef Google Scholar
[27]	Prasad B., Richter P, Vadakedath N, et al. (2021). How the space environment influences organisms: An astrobiological perspective and review. Int. J. Astrobiol. 20:159−177. DOI:10.1017/S1473550421000057 View in Article CrossRef Google Scholar
[28]	Liu J., Zhang W., He K., et al. (2022). Survival of the magnetotactic bacterium Magnetospirillum gryphiswaldense exposed to Earth’s lower near space. Sci. Bull. 67:1335−1339. DOI:10.1016/j.scib.2022.03.005 View in Article CrossRef Google Scholar
[29]	Wood C., Bruinink A., Trembath-Reichert E., et al. (2024). Active microbiota persist in dry permafrost and active layer from Elephant Head, Antarctica. ISME Commun. 4:ycad002. DOI:10.1093/ismeco/ycad002 View in Article CrossRef Google Scholar
[30]	Siliakus M.F., van der Oost J. and Kengen S.W. (2017). Adaptations of archaeal and bacterial membranes to variations in temperature, pH and pressure. Extremophiles. 21:651−670. DOI:10.1007/s00792-017-0939-x View in Article CrossRef Google Scholar
[31]	Obruča S., Dvořák P., Sedláček P., et al. (2022). Polyhydroxyalkanoates synthesis by halophiles and thermophiles: Towards sustainable production of microbial bioplastics. Biotechnol. Adv. 58:107906. DOI:10.1016/j.biotechadv.2022.107906 View in Article CrossRef Google Scholar
[32]	Somayaji A., Dhanjal C.R., Lingamsetty R., et al. (2022). An insight into the mechanisms of homeostasis in extremophiles. Microbiol. Res. 263:127115. DOI:10.1016/j.micres.2022.127115 View in Article CrossRef Google Scholar
[33]	Sylvia D.M., Fuhrmann J.J., Hartel P.G., et al. (2021). Bacteria and archaea. Terry Gentry, Jeffry J. F., David A.Z.(ed). Principles and applications of soil microbiology (Elsevier, Amsterdam), pp:111-148. DOI:10.1016/B978-0-12-820202-9.00005-8 View in Article Google Scholar
[34]	Abath N., Ferrada E., Barve A., et al. (2013). Growth temperature and genome size in bacteria are negatively correlated, suggesting genomic streamlining during thermal adaptation. Genome biol. Evol. 5:966−977. DOI:10.1093/gbe/evt050 View in Article CrossRef Google Scholar
[35]	Hu E.Z., Lan X.R., Liu Z.L., et al. (2022). A positive correlation between GC content and growth temperature in prokaryotes. BMC genomics 23:110. DOI:10.1186/s12864-022-08353-7 View in Article CrossRef Google Scholar
[36]	Hurst L.D. and Merchant A.R. (2001). High guanine–cytosine content is not an adaptation to high temperature: A comparative analysis amongst prokaryotes. Proc. Biol. Sci. 268:493−497. DOI:10.1098/rspb.2000.1397 View in Article CrossRef Google Scholar
[37]	Ahmad A., Rahamtullah and Mishra R. (2022). Structural and functional adaptation in extremophilic microbial α-amylases. Biophys. Rev. 14:499−515. DOI:10.1007/s12551-022-00931-z View in Article CrossRef Google Scholar
[38]	Liu L., Cai L., Chu Y., et al. (2022). Thermostability mechanisms of β-agarase by analyzing its structure through molecular dynamics simulation. AMB Express 12:50. DOI:10.1186/s13568-022-01394-x View in Article CrossRef Google Scholar
[39]	Lewin A., Wentzel A. and Valla S. (2013). Metagenomics of microbial life in extreme temperature environments. Curr. Opin Biotech. 24:516−525. DOI:10.1016/j.copbio.2012.10.012 View in Article CrossRef Google Scholar
[40]	Collins T. and Margesin R. (2019). Psychrophilic lifestyles: Mechanisms of adaptation and biotechnological tools. Appl. Microbiol. Biot. 103:2857−2871. DOI:10.1007/s00253-019-09659-5 View in Article CrossRef Google Scholar
[41]	Truongvan N., Jang S. and Lee C. (2016). Flexibility and stability trade-off in active site of cold-adapted Pseudomonas mandelii esterase EstK. Biochemistry. 55:3542−3549. DOI:10.1021/acs.biochem.6b00177 View in Article CrossRef Google Scholar
[42]	Goordial J., Raymond-Bouchard I., Zolotarov Y.,et al. (2016). Cold adaptive traits revealed by comparative genomic analysis of the eurypsychrophile Rhodococcus sp. JG3 isolated from high elevation McMurdo Dry Valley permafrost, Antarctica. FEMS microbiol ecol, 92: fiv154. DOI:10.1093/femsec/fiv154 View in Article Google Scholar
[43]	Yusof N.A., Hashim N.H.F. and Bharudin I. (2021). Cold adaptation strategies and the potential of psychrophilic enzymes from the antarctic yeast, Glaciozyma antarctica PI12. J. Fungi 7:528. DOI:10.3390/jof7070528 View in Article CrossRef Google Scholar
[44]	Casanueva A., Tuffin M., Cary C.,et al. (2010). Molecular adaptations to psychrophily: The impact of ‘omic’technologies. Trends Microbiol. 18:374−381. DOI:10.1016/j.tim.2010.05.002 View in Article CrossRef Google Scholar
[45]	Nayak T., Sengupta I. and Dhal P.K. (2021). A new era of radiation resistance bacteria in bioremediation and production of bioactive compounds with therapeutic potential and other aspects: An in-perspective review. J. Environl. Radioactiv. 237:106696. DOI:10.1016/j.jenvrad.2021.106696 View in Article CrossRef Google Scholar
[46]	Jin M., Xiao A., Zhu L., et al. (2019). The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications. AMB express 9:1−12. DOI:10.1186/s13568-019-0862-x View in Article CrossRef Google Scholar
[47]	Liu F., Li N. and Zhang Y. (2023). The radioresistant and survival mechanisms of Deinococcus radiodurans. Radiat. Med. Protect. 4:70−79. DOI:10.1016/j.radmp.2023.03.001 View in Article CrossRef Google Scholar
[48]	Makarova K.S., Aravind L., Wolf Y.I., et al. (2001). Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics. Microbiol. Mol. Biol. Rev. 65:44−79. DOI:10.1128/MMBR.65.1.44-79.2001 View in Article CrossRef Google Scholar
[49]	Timmins J. and Moe E. (2016). A decade of biochemical and structural studies of the DNA repair machinery of Deinococcus radiodurans: Major findings, functional and mechanistic insight and challenges. Comput. Struct. Biotechnol J. 14:168−176. DOI:10.1016/j.csbj.2016.04.001 View in Article CrossRef Google Scholar
[50]	Cho C., Lee G.W., Hong S.H., et al. (2019). Novel functions of peroxiredoxin Q from Deinococcus radiodurans R1 as a peroxidase and a molecular chaperone. FEBS Lett. 593:219−229. DOI:10.1002/1873-3468.13302 View in Article CrossRef Google Scholar
[51]	Lim S., Jung J.H., Blanchard L. and de Groot A. (2019). Conservation and diversity of radiation and oxidative stress resistance mechanisms in Deinococcus species. FEMS microbiol. Rev. 43:19−52. DOI:10.1093/femsre/fuy037 View in Article CrossRef Google Scholar
[52]	Hibshman J.D., Clegg J. S. and Goldstein B. (2020). Mechanisms of desiccation tolerance: Themes and variations in brine shrimp, roundworms, and tardigrades. Front. Physiol. 11:592016. DOI:10.3389/fphys.2020.592016 View in Article CrossRef Google Scholar
[53]	Karlinsey J.E., Fung A.M., Johnston N., et al. (2022). Cyclopropane fatty acids are important for Salmonella enterica serovar Typhimurium virulence. Infect. Immune. 90:e00479−21. DOI:10.1128/IAI.00479-21 View in Article CrossRef Google Scholar
[54]	Olgenblum G.I., Hutcheson B.O., Pielak, G.J.,et al. (2024). Protecting proteins from desiccation stress using molecular glasses and gels. Chem. Rev. 124:5668−5694. DOI:10.1021/acs.chemrev.3c00752 View in Article CrossRef Google Scholar
[55]	Marks R.A., Ekwealor J.T.B., Artur M.A.S., et al. (2025). Life on the dry side: A roadmap to understanding desiccation tolerance and accelerating translational applications. Nat. Commun. 16:3284. DOI:10.1038/s41467-025-58656-y View in Article CrossRef Google Scholar
[56]	Claudia M.V., Javiera A.A., Sebastián N.S., et al. (2024). Interplay between desiccation and oxidative stress responses in iron-oxidizing acidophilic bacteria. J. Biotechnol. 383:64−72. DOI:10.1016/j.jbiotec.2024.01.017 View in Article CrossRef Google Scholar
[57]	Calahan D., Dunham M., DeSevo C., et al, (2011). Genetic analysis of desiccation tolerance in Saccharomyces cerevisiae. Genetics. 189: 507-519. DOI: 10.1534/genetics.111.130369 View in Article Google Scholar
[58]	Colica G., Li H., Rossi F., et al. (2014). Microbial secreted exopolysaccharides affect the hydrological behavior of induced biological soil crusts in desert sandy soils. Soil Biol. Biochem. 68:62−70. DOI:10.1016/j.soilbio.2013.09.017 View in Article CrossRef Google Scholar
[59]	Nawaz M., Hassan M.U., Chattha M.U., et al. (2022). Trehalose: A promising osmo-protectant against salinity stress—physiological and molecular mechanisms and future prospective. Mol. Biol. Rep. 49:11255−11271. DOI:10.1007/s11033-022-07681-x View in Article CrossRef Google Scholar
[60]	Khaleque H.N., González C., Shafique R., et al. (2019). Uncovering the mechanisms of halotolerance in the extremely acidophilic members of the Acidihalobacter genus through comparative genome analysis. Front. Microbiol. 10:155. DOI:10.3389/fmicb.2019.00155 View in Article CrossRef Google Scholar
[61]	Beblo-Vranesevic K., Huber H. and Rettberg P. (2017). High tolerance of Hydrogenothermus marinus to sodium perchlorate. Front. Microbiol. 8:1369. DOI:10.3389/fmicb.2017.01369 View in Article CrossRef Google Scholar
[62]	Heinz J., Waajen A.C., Airo A., et al. (2019). Bacterial growth in chloride and perchlorate brines: Halotolerances and salt stress responses of Planococcus halocryophilus. Astrobiology 19:1377−1387. DOI:10.1089/ast.2019.2069 View in Article CrossRef Google Scholar
[63]	Kyriatzi A., Tzivras G., Pirintsos S., et al. (2021) Biotechnology under extreme conditions: Lichens after extreme UVB radiation and extreme temperatures produce large amounts of hydrogen. J. Biotechnol. 342: 128-138. DOI: 10.1016/j.jbiotec.2021.10.011. View in Article Google Scholar
[64]	de la Torre Noetzel R., Miller A.Z., de la Rosa J.M., et al. (2018). Cellular responses of the lichen Circinaria gyrosa in Mars-like conditions. Front. Microbiol. 9:308. DOI:10.3389/fmicb.2018.00308 View in Article CrossRef Google Scholar
[65]	Rokaya N., Carr E.C., Tiwari S., et al. (2025). Design of co-culturing system of diazotrophic cyanobacteria and filamentous fungi for potential application in self-healing concrete. Mater Today Commun. 44:112093. DOI:10.1016/j.mtcomm.2025.112093 View in Article CrossRef Google Scholar
[66]	Jimenez M., L’Heureux J., Kolaya E. et al. (2024). Synthetic extremophiles via species-specific formulations improve microbial therapeutics. Nat. Mater. 23:1436−1443. DOI:10.1038/s41563-024-01937-6 View in Article CrossRef Google Scholar
[67]	Chen J., Li, Y., and Mahadevan R. (2023). Genetic engineering of Acidithiobacillus ferridurans using CRISPR systems to mitigate toxic release in biomining. Environ. Sci. Technol. 57:12315−12324. DOI:10.1021/acs.est.3c02492 View in Article CrossRef Google Scholar
[68]	Chen J., Liu Y., Diep P., et al. (2022). Genetic engineering of extremely acidophilic Acidithiobacillus species for biomining: Progress and perspectives. J. Hazard. Mater. 438:129456. DOI:10.1016/j.jhazmat.2022.129456 View in Article CrossRef Google Scholar
[69]	Wang Q., Hu Z., Li Z., et al (2023). Exploring the application and prospects of synthetic biology in engineered living materials. Adv. Mater. 35: 2305828. DOI: 10.1002/adma.202305828. View in Article Google Scholar
[70]	Li F., Li X., Ye L., et al. (2022) A genetically engineered composite biofilm for microbial induced calcium carbonate precipitation by synergic effect of urease, protein adhesive and xanthan gum. J. Environ. Chem. Eng. 10: 108431. DOI: 10.1016/j.jece.2022.108431. View in Article Google Scholar
[71]	Berepiki A., Hitchcock A., Moore C.M., et al. (2016). Tapping the unused potential of photosynthesis with a heterologous electron sink. ACS Synth. Biol. 5:1369−1375. DOI:10.1021/acssynbio.6b00100 View in Article CrossRef Google Scholar
[72]	Rosa L. T., Vernhes É., Soulet A.L., et al. (2024). Structural insights into the mechanism of DNA branch migration during homologous recombination in bacteria. EMBO J. 43:6180−6198. DOI:10.1038/s44318-024-00264-5 View in Article CrossRef Google Scholar
[73]	Hertzog M., Perry T.N., Dupaigne P., et al. (2023). Assembly mechanism and cryoEM structure of RecA recombination nucleofilaments from Streptococcus pneumoniae. Nucleic Acids Res. 51:2800−2817. DOI:10.1093/nar/gkad080 View in Article CrossRef Google Scholar
[74]	Horne W.H., Volpe R.P., Korza G., et al. (2022). Effects of desiccation and freezing on microbial ionizing radiation survivability: Considerations for Mars sample return. Astrobiology, 22:1337−1350. DOI:10.1089/ast.2022.0065 View in Article CrossRef Google Scholar
[75]	Kochhar N., Kumar I.K., Shrivastava S., et al. (2022). Perspectives on the microorganism of extreme environments and their applications. Curr. Res. Microb. Sci. 3:100134. DOI:10.1016/j.crmicr.2022.100134 View in Article CrossRef Google Scholar
[76]	Jomova K., Alomar S.Y., Alwasel S.H., et al. (2024). Several lines of antioxidant defense against oxidative stress: Antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants. Arch Toxicol, 98:1323−1367. DOI:10.1007/s00204-024-03696-4 View in Article CrossRef Google Scholar
[77]	Elsaesser A., Burr D.J., Mabey P., et al. (2023). Future space experiment platforms for astrobiology and astrochemistry research. npj Microgravity 9:43. DOI:10.1038/s41526-023-00292-1 View in Article CrossRef Google Scholar
[78]	Sweet P., Ball N., Vu S., Anderson L., et al. (2025). Bionutrients-1: Utilizing genomics and transcriptomics to assess the reliability of microorganisms for in situ nutrient production on long duration missions. 2025 NASA HRP IWS human research program investigator's workshop. https://ntrs.nasa.gov/citations/20250000598. View in Article Google Scholar
[79]	Zhang B., Zhong R., Shen G., et al. (2025). The space radiobiological exposure facility on the China space station. Astrobiology 25:32−41. DOI:10.1089/ast.2024.0027 View in Article CrossRef Google Scholar
[80]	NASA. (2023). Exposed: International space station tests organisms and materials in space. https://www.nasa.gov/missions/station/iss-research/exposed-international-space-station-tests-organisms-materials-in-space/ View in Article Google Scholar
[81]	Billi D. (2019). Desert cyanobacteria under space and planetary simulations: A tool for searching for life beyond Earth and supporting human space exploration. Int. J. Astrobiol. 18:483−489. DOI:10.1017/S147355041800037X View in Article CrossRef Google Scholar
[82]	Ott E., Kawaguchi Y., Kölbl D., et al. (2020). Molecular repertoire of Deinococcus radiodurans after 1 year of exposure outside the International Space Station within the Tanpopo mission. Microbiome. 8:1−16. DOI:10.1186/s40168-020-00927-5 View in Article CrossRef Google Scholar
[83]	Deshevaya E.A., Fialkina S.V., Shubralova E.V., et al. (2024). Survival of microorganisms during two-year exposure in outer space near the ISS. Sci. Rep. 14:334. DOI:10.1038/s41598-023-49525-z View in Article CrossRef Google Scholar
[84]	Gomoiu I., Chatzitheodoridis E., Vadrucci S., et al. (2013). The effect of spaceflight on growth of Ulocladium chartarum colonies on the international space station. PLoS One. 8:e62130. DOI:10.1371/journal.pone.0062130 View in Article CrossRef Google Scholar
[85]	Senatore G., Mastroleo F., Leys N., et al. (2018). Effect of microgravity & space radiation on microbes. Future Microbiol. 13:831−847. DOI:10.2217/fmb-2017-0251 View in Article CrossRef Google Scholar
[86]	Sengupta P., Muthamilselvi Sivabalan S.K., Singh N.K., et al. (2024). Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station. Microbiome. 12:62. DOI:10.1186/s40168-024-01777-1 View in Article CrossRef Google Scholar
[87]	Sowmeya V.G. and Sathiavelu M. (2024). Biofilm dynamics in space and their potential for sustainable space exploration–A comprehensive review. Life Sci. Space Res. 44:108−121. DOI:10.1016/j.lssr.2024.08.006 View in Article CrossRef Google Scholar
[88]	Acres J.M., Youngapelian M.J. and Nadeau J. (2021). The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis. npj Microgravity 7:7. DOI:10.1038/s41526-021-00135-x View in Article CrossRef Google Scholar
[89]	Kim W., Tengra F.K., Young Z., et al. (2013) Spaceflight promotes biofilm formation by Pseudomonas aeruginosa. PloS one. 8: e62437. DOI: 10.1371/journal.pone.0062437 View in Article Google Scholar
[90]	Wilson J.W., Ott C.M., Zu Bentrup K.H., et al. (2007) Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq. Proc. Natl. Acad. Sci. USA. 104: 16299-16304. DOI: 10.1073/pnas.0707155104 View in Article Google Scholar
[91]	Flores P., McBride S.A., Galazka J.M., et al. (2023). Biofilm formation of Pseudomonas aeruginosa in spaceflight is minimized on lubricant impregnated surfaces. npj Microgravity 9:66. DOI:10.1038/s41526-023-00316-w View in Article CrossRef Google Scholar
[92]	Marra D., Rizzo M. and Caserta S. (2025). Microfluidics unveils role of gravity and shear stress on Pseudomonas fluorescens motility and biofilm growth. npj Biofilms Microbi. 11:122. DOI:10.1038/s41522-025-00744-4 View in Article CrossRef Google Scholar
[93]	Moreno-Villanueva M., Wong M., Lu T., et al. (2017). Interplay of space radiation and microgravity in DNA damage and DNA damage response. npj Microgravity. 3:14. DOI:10.1038/s41526-017-0019-7 View in Article CrossRef Google Scholar
[94]	Zhao L., Zhang G., Tang A., et al. (2023). Microgravity alters the expressions of DNA repair genes and their regulatory miRNAs in space-flown Caenorhabditis elegans. Life Sci. Space Res. 37:25−38. DOI:10.1016/j.lssr.2023.02.002 View in Article CrossRef Google Scholar
[95]	Irby I. and Broddrick J.T. (2024). Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions. Nat. Commun. 15:3474. DOI:10.1038/s41467-023-42104-w View in Article CrossRef Google Scholar
[96]	Revellame E.D., Aguda R., Chistoserdov A., et al. (2021). Microalgae cultivation for space exploration: Assessing the potential for a new generation of waste to human life-support system for long duration space travel and planetary human habitation. Algal Research. 55:102258. DOI:10.1016/j.algal.2021.102258 View in Article CrossRef Google Scholar
[97]	Napoli A., Micheletti D., Pindo M., et al. (2022). Absence of increased genomic variants in the cyanobacterium Chroococcidiopsis exposed to Mars-like conditions outside the space station. Sci. Rep. 12:8437. DOI:10.1038/s41598-022-12631-5 View in Article CrossRef Google Scholar
[98]	Billi D., Mosca C., Fagliarone C., et al. (2020). Exposure to low Earth orbit of an extreme-tolerant cyanobacterium as a contribution to lunar astrobiology activities. Int. J. Astrobiol. 19:53−60. DOI:10.1017/S1473550419000168 View in Article CrossRef Google Scholar
[99]	Kawaguchi Y., Yang Y., Kawashiri N., et al. (2013). The possible interplanetary transfer of microbes: Assessing the viability of Deinococcus spp. under the ISS environmental conditions for performing exposure experiments of microbes in the Tanpopo mission. Origins Life Evol. B. 43:411−428. DOI:10.1007/s11084-013-9346-1 View in Article CrossRef Google Scholar
[100]	Cortesão M., Fuchs F.M., Commichau F.M., et al. (2019). Bacillus subtilis spore resistance to simulated Mars surface conditions. Front. Microbiol. 10:333. DOI:10.3389/fmicb.2019.00333 View in Article CrossRef Google Scholar
[101]	Panitz C., Horneck G., Rabbow E., et al. (2015). The SPORES experiment of the EXPOSE-R mission: Bacillus subtilis spores in artificial meteorites. Int. J. Astrobiol. 14:105−114. DOI:10.1017/S1473550414000251 View in Article CrossRef Google Scholar
[102]	Onofri S., de Vera J.P., Zucconi L. et al. (2015). Survival of Antarctic cryptoendolithic fungi in simulated Martian conditions on board the International Space Station. Astrobiology 15:1052−1059. DOI:10.1089/ast.2015.1324 View in Article CrossRef Google Scholar
[103]	Santomartino R., Waajen A.C., De Wit W., et al. (2020). No effect of microgravity and simulated Mars gravity on final bacterial cell concentrations on the International Space Station: Applications to space bioproduction. Front. Microbiol. 11:579156. DOI:10.3389/fmicb.2020.579156 View in Article CrossRef Google Scholar
[104]	Cockell C.S., Santomartino R., Finster K., et al. (2020). Space station biomining experiment demonstrates rare earth element extraction in microgravity and Mars gravity. Nat. Commun. 11:5523. DOI:10.1038/s41467-020-19276-w View in Article CrossRef Google Scholar
[105]	Cockell C.S., Santomartino R., Finster K., et al. (2021). Microbially-enhanced vanadium mining and bioremediation under micro-and Mars gravity on the International Space Station. Front. Microbiol. 12:641387. DOI:10.3389/fmicb.2021.641387 View in Article CrossRef Google Scholar
[106]	Gu J.D. (2007). Microbial colonization of polymeric materials for space applications and mechanisms of biodeterioration: A review. Int. Biodeter. Biodeg. 59:170−179. DOI:10.1016/j.ibiod.2006.08.010 View in Article CrossRef Google Scholar
[107]	Zhang W., Chen N., Yuan J., et al. Initial attempt: Design and application of microorganism-material interaction test on On-orbit space microgravity conditions. Acta Astronaut. 228: 384-395. DOI:10.1016/j.actaastro.2024.12.006 View in Article Google Scholar
[108]	Mahnert A., Verseux C., Schwendner P., et al. (2021). Microbiome dynamics during the HI - SEAS IV mission, and implications for future crewed missions beyond Earth. Microbiome. 9:27. DOI:10.1186/s40168-020-00959-x View in Article CrossRef Google Scholar
[109]	Cowen D., Zhang R. and Komorowski M. (2024). Infections in long - duration space missions. The Lancet Microbe. 5:100875. DOI:10.1016/S2666-5247(24)00098-3 View in Article CrossRef Google Scholar
[110]	Romsdahl J., Blachowicz A., Chiang A.J., et al. (2018). Characterization of Aspergillus niger isolated from the international space station. mSystems. 3:e00112−18. DOI:10.1128/mSystems.00112-18 View in Article CrossRef Google Scholar
[111]	Simoes M.F., Antunes A. (2021). Microbial pathogenicity in space. Pathogens 10:450. DOI:10.3390/pathogens10040450 View in Article CrossRef Google Scholar
[112]	Afshinnekoo E., Scott R.T., MacKay M.J., et al. (2020). Fundamental biological features of spaceflight: Advancing the field to enable deep - space exploration. Cell. 183:1162−1184. DOI:10.1016/j.cell.2020.10.050 View in Article CrossRef Google Scholar
[113]	Urbaniak C., Lorenzi H., Thissen J., et al. (2020). The influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivation. Microbiome. 8:56. DOI:10.1186/s40168-020-00830-z View in Article CrossRef Google Scholar
[114]	Tozzo P., Delicati A. and Caenazzo L. (2022). Skin microbial changes during space flights: A systematic review. Life 12:1498. DOI:10.3390/life12101498 View in Article CrossRef Google Scholar
[115]	Slaba T.C., Rahmanian S., George S., et al. (2025). Validated space radiation exposure predictions from earth to mars during Artemis-I. npj Microgravity 11:6. DOI:10.1038/s41526-025-00459-y View in Article CrossRef Google Scholar
[116]	Berger T., Matthiä D., Burmeister S., et al. (2020). Long term variations of galactic cosmic radiation on board the International Space Station, on the Moon and on the surface of Mars. J. Space Weather Spac. 10:34. DOI:10.1051/swsc/2020028 View in Article CrossRef Google Scholar
[117]	George S.P., Gaza R., Matthiä D., et al. (2024). Space radiation measurements during the Artemis I lunar mission. Nature 634:48−52. DOI:10.1038/s41586-024-07927-7 View in Article CrossRef Google Scholar
[118]	Maier S., Tamm A., Wu D., et al. (2018). Photoautotrophic organisms control microbial abundance, diversity, and physiology in different types of biological soil crusts. ISME J. 12:1032−1046. DOI:10.1038/s41396-018-0062-8 View in Article CrossRef Google Scholar
[119]	Guida G., Nicosia A., Settanni L., et al. (2023). A review on effects of biological soil crusts on hydrological processes. Earth-Sci. Rev. 243:104516. DOI:10.1016/j.earscirev.2023.104516 View in Article CrossRef Google Scholar
[120]	Hartmann M. and Six J. (2023). Soil structure and microbiome functions in agroecosystems. Nat. Rev. Earth Env. 4:4−18. DOI:10.1038/s43017-022-00366-w View in Article CrossRef Google Scholar
[121]	Rabot E., Wiesmeier M., Schlüter S., et al. (2018). Soil structure as an indicator of soil functions: A review. Geoderma 314:122−137. DOI:10.1016/j.geoderma.2017.11.009 View in Article CrossRef Google Scholar
[122]	Cao Y., Xiao B. and Ghanbarian B. (2024). Biocrusts enhance soil structural stability during freeze-thaw cycles and improve soil erosion resistance in cold-winter drylands. Catena 243:108206. DOI:10.1016/j.catena.2024.108206 View in Article CrossRef Google Scholar
[123]	Rodriguez-Caballero E., Stanelle T., Egerer S., et al. (2022). Global cycling and climate effects of aeolian dust controlled by biological soil crusts. Nat. Geosci. 15:458−463. DOI:10.1038/s41561-022-00942-1 View in Article CrossRef Google Scholar
[124]	Liu Y., Cockell C.S., Wang G., et al. (2008). Control of Lunar and Martian dust—Experimental insights from artificial and natural cyanobacterial and algal crusts in the desert of Inner Mongolia. China. Astrobiology 8:75−86. DOI:10.1089/ast.2007.0122 View in Article CrossRef Google Scholar
[125]	Yu X., Xiao B., Cao Y., et al. (2024). Microbial-induced extracellular polymers are fundamentally responsible for the mechanical stability of biocrusts in drylands. Catena 245:108349. DOI:10.1016/j.catena.2024.108349 View in Article CrossRef Google Scholar
[126]	Lan S., Ouyang H., Wu L.,et al. (2017). Biological soil crust community types differ in photosynthetic pigment composition, fluorescence and carbon fixation in Shapotou region of China. Appl. Soil Ecology 111:9−16. DOI:10.1016/j.apsoil.2016.11.009 View in Article CrossRef Google Scholar
[127]	Mackelprang R., Vaishampayan P., Fisher K. (2022). Adaptation to environmental extremes structures functional traits in biological soil crust and hypolithic microbial communities. Msystems 7:e01419−21. DOI:10.1128/msystems.01419-21 View in Article CrossRef Google Scholar
[128]	Garcia-Pichel F. (2023). The microbiology of biological soil crusts. Annual Rev. Microbiol. 77:149−171. DOI:10.1146/annurev-micro-032521-015202 View in Article CrossRef Google Scholar
[129]	Wang C. and Kuzyakov Y. (2024). Soil organic matter priming: The pH effects. Global Change Biol. 30:e17349. DOI:10.1111/gcb.17349 View in Article CrossRef Google Scholar
[130]	Xiao B., Ma S., and Hu K. (2019). Moss biocrusts regulate surface soil thermal properties and generate buffering effects on soil temperature dynamics in dryland ecosystem. Geoderma 351:9−24. DOI:10.1016/j.geoderma.2019.05.017 View in Article CrossRef Google Scholar
[131]	Chilton A.M., Neilan B.A. and Eldridge D.J. (2018). Biocrust morphology is linked to marked differences in microbial community composition. Plant Soil. 429:65−75. DOI:10.1007/s11104-017-3442-3 View in Article CrossRef Google Scholar
[132]	Liao K., Chen C., Ye W., et al. (2024). The adaptability, distribution, ecological function and restoration application of biological soil crusts on metal tailings: A critical review. Sci. Total Environ. 927:172169. DOI:10.1016/j.scitotenv.2024.172169 View in Article CrossRef Google Scholar
[133]	Wild B., Gerrits R., Bonneville S. (2022). The contribution of living organisms to rock weathering in the critical zone. npj Mat. Degrad 6:98. DOI:10.1038/s41529-022-00312-7 View in Article CrossRef Google Scholar
[134]	Armbrust E.V. (2009). The life of diatoms in the world's oceans. Nature 459:185−192. DOI:10.1038/nature08057 View in Article CrossRef Google Scholar
[135]	Liu D. and Zhang Y.X. (2025). Diatom-driven activation of in-situ lunar resource utilization for space farming. Biogeotech. 3:100162. DOI:10.1016/j.bgtech.2025.100162 View in Article CrossRef Google Scholar
[136]	Resl P., Bujold A.R., Tagirdzhanova G., et al. (2022). Large differences in carbohydrate degradation and transport potential among lichen fungal symbionts. Nat. Commun. 13:2634. DOI:10.1038/s41467-022-30218-6 View in Article CrossRef Google Scholar
[137]	Koehle A.P., Brumwell S.L., Seto E.P., et al. (2023). Microbial applications for sustainable space exploration beyond low Earth orbit. npj Microgravity 9:47. DOI:10.1038/s41526-023-00285-0 View in Article CrossRef Google Scholar
[138]	Averesch N.J., Berliner A.J., Nangle S.N., et al. (2023). Microbial biomanufacturing for space-exploration—what to take and when to make. Nat. Commun. 14:2311. DOI:10.1038/s41467-023-37910-1 View in Article CrossRef Google Scholar
[139]	Verseux C., Baqué M., Lehto K. et al. (2016). Sustainable life support on Mars–the potential roles of cyanobacteria. Int. J. Astrobiol. 15:65−92. DOI:10.1017/S147355041500021X View in Article CrossRef Google Scholar
[140]	Xia Y., Yuan Y., Li C., et al. (2023). Phosphorus-solubilizing bacteria improve the growth of Nicotiana benthamiana on lunar regolith simulant by dissociating insoluble inorganic phosphorus. Commun. Biology. 6:1039. DOI:10.1038/s42003-023-05391-z View in Article CrossRef Google Scholar
[141]	Aung K.M.M. and Ting Y. (2005). Bioleaching of spent fluid catalytic cracking catalyst using Aspergillus niger. J. biotechnol. 116:159−170. DOI:10.1016/j.jbiotec.2004.10.008 View in Article CrossRef Google Scholar
[142]	Jung H., Inaba Y. and Banta S. (2022). Genetic engineering of the acidophilic chemolithoautotroph Acidithiobacillus ferrooxidans. Trends Biotechnol. 40:677−692. DOI:10.1016/j.tibtech.2021.10.004 View in Article CrossRef Google Scholar
[143]	Johnson D.B. (2014). Biomining—biotechnologies for extracting and recovering metals from ores and waste materials. Current Opin. Biotech. 30:24−31. DOI:10.1016/j.copbio.2014.04.008 View in Article CrossRef Google Scholar
[144]	Li C., Hu H., Yang M.F., et al. (2022). Characteristics of the lunar samples returned by the Chang’E-5 mission. Natl. Sci. Rev. 9:nwab188. DOI:10.1093/nsr/nwab188 View in Article CrossRef Google Scholar
[145]	Gumulya Y., Zea L. and Kaksonen A.H. (2022). In situ resource utilisation: The potential for space biomining. Miner. Eng. 176:107288. DOI:10.1016/j.mineng.2021.107288 View in Article CrossRef Google Scholar
[146]	Hazen R.M., Downs R.T., Morrison S.M., et al. (2023). On the diversity and formation modes of martian minerals. J. Geophys. Res- Planet. 128:e2023JE007865. DOI:10.1029/2023JE007865 View in Article CrossRef Google Scholar
[147]	Jaiswal M. and Srivastava S. (2024). A review on sustainable approach of bioleaching of precious metals from electronic wastes. J. Hazard. Mater. Adv. 14:100435. DOI:10.1016/j.hazadv.2024.100435 View in Article CrossRef Google Scholar
[148]	Volger, R., Pettersson G.M., Brouns S.J.J., et al. (2020). Mining moon & mars with microbes: Biological approaches to extract iron from Lunar and Martian regolith. Planet. Space Sci. 184:104850. DOI:10.1016/j.pss.2020.104850 View in Article CrossRef Google Scholar
[149]	Tiquia-Arashiro S. and Rodrigues D.F. (2016). Nanoparticles synthesized by microorganisms. Tiquia-Arashiro S., Rodrigues D.F. (eds). Extremophiles: Applications in nanotechnology. (Springer-International publisher), pp:1-15. DOI:10.1007/978-3-319-45215-9. View in Article Google Scholar
[150]	Yang Y., Li H., Yuan Y., et al. (2025). Microbiological mechanisms and effects of dissimilatory iron reduction on combined contaminants bio-transformation: A review. Process Biochem. 153:47−65. DOI:10.1016/j.procbio.2025.03.004 View in Article CrossRef Google Scholar
[151]	Olsson-Francis K. and Cockell C.S. (2010). Use of cyanobacteria for in-situ resource use in space applications. Planet. Space Sci. 58:1279−1285. DOI:10.1016/j.pss.2010.05.005 View in Article CrossRef Google Scholar
[152]	Spietz R.L., Payne D., Szilagyi R.,et al. (2022). Reductive biomining of pyrite by methanogens. Trends Microbiol. 30:1072−1083. DOI:10.1016/j.tim.2022.05.005 View in Article CrossRef Google Scholar
[153]	Vo P.H., Danaee S., Hai H.T.N., et al. (2024). Biomining for sustainable recovery of rare earth elements from mining waste: A comprehensive review. Sci. Total Environ. 908:168210. DOI:10.1016/j.scitotenv.2023.168210 View in Article CrossRef Google Scholar
[154]	Castelein S.M., Aarts T.F., Schleppi J., et al. (2021). Iron can be microbially extracted from Lunar and Martian regolith simulants and 3D printed into tough structural materials. Plos one 16:e0249962. DOI:10.1371/journal.pone.0249962 View in Article CrossRef Google Scholar
[155]	McLeod C.L. and Krekeler M.P. (2017). Sources of extraterrestrial rare earth elements: To the Moon and beyond. Res. 6:40. DOI:10.3390/resources6030040 View in Article CrossRef Google Scholar
[156]	Zhang J. and Liu J. (2024). Thorium anomaly on the lunar surface and its indicative meaning. Acta Geochim. 43:507−519. DOI:10.1007/s11631-023-00670-2 View in Article CrossRef Google Scholar
[157]	VanBommel S.J., Sharma S., Kizovski T.V., et al. (2025). Rare earth element assessment in Jezero crater using the Planetary Instrument for X-ray Lithochemistry on the Mars 2020 rover Perseverance: A case study of cerium. Icarus 425:116355. DOI:10.1016/j.icarus.2024.116355 View in Article CrossRef Google Scholar
[158]	Ren K., Wang Q., Cao Y., et al. (2021). Multicomponent rare-earth cerate and zirconocerate ceramics for thermal barrier coating materials. J. Eur. Ceram. Soc. 41:1720−1725. DOI:10.1016/j.jeurceramsoc.2020.10.005 View in Article CrossRef Google Scholar
[159]	Jing H., Geng L., Qiu S., et al. (2023). Research progress of rare earth composite shielding materials. J. Rare Earth 41:32−41. DOI:10.1016/j.jre.2022.06.004 View in Article CrossRef Google Scholar
[160]	Srikant, Sharma V.K., Kumar V., et al. (2021). A review of recent research on rare earth particulate composite materials and structures with their applications. Trans. Indian Inst. Met. 74:2569−2581. DOI:10.1007/s12666-021-02338-y View in Article CrossRef Google Scholar
[161]	Hossain M.K., Ahmed M.H., Khan M.I., et al. (2021). Recent progress of rare earth oxides for sensor, detector, and electronic device applications: A review. ACS Appl. Electron. Mater. 3:4255−4283. DOI:10.1021/acsaelm.1c00703 View in Article CrossRef Google Scholar
[162]	Hossain M.K., Raihan G.A., Akbar M.A., et al. (2022). Current applications and future potential of rare earth oxides in sustainable nuclear, radiation, and energy devices: A review. ACS Appl. Electron. Mater. 4:3327−3353. DOI:10.1021/acsaelm.2c00069 View in Article CrossRef Google Scholar
[163]	Zhang X., Wang H., He Y., et al. (2025). Application of PVA fiber-reinforced biocement for the stabilization of dispersive soil: Water stability, mechanical properties, and modification mechanism. Mater. Today Commun. 48:113439. DOI:10.1016/j.mtcomm.2025.113439 View in Article CrossRef Google Scholar
[164]	Zhang X., Wang H., Wang Y., et al. (2024). Improved methods, properties, applications and prospects of microbial induced carbonate precipitation (MICP) treated soil: A review. Biogeotech. 3:100123. DOI:10.1016/j.bgtech.2024.100123 View in Article CrossRef Google Scholar
[165]	Gebru K.A., Kidanemariam T.G., Gebretinsae, H. K. (2021) Bio-cement production using microbially induced calcite precipitation (MICP) method: A review. Chem. Eng. Sci. 238: 116610. DOI:10.1016/j.ces.2021.116610. View in Article Google Scholar
[166]	Gao Y., Wang L., He J., et al. (2022). Denitrification-based MICP for cementation of soil: Treatment process and mechanical performance. Acta Geotech. 17:3799−3815. DOI:10.1007/s11440-022-01489-6 View in Article CrossRef Google Scholar
[167]	O’Donnell ST, Kavazanjian E and Rittmann B.E. (2017). MIDP: Liquefaction mitigation via microbial denitrification as a two-Stage process II: MICP. J. Geotech. Geoenviron. 143:04017095. DOI:10.1061/(ASCE)GT.1943-5606.0001806 View in Article CrossRef Google Scholar
[168]	Shivaprakash S.H. and Burns S.E. (2025). Microbial interactions during carbonate biomineralization via urea hydrolysis metabolic pathway. Acta Geotech. 20:3929−3950. DOI:10.1007/s11440-025-02609-8 View in Article CrossRef Google Scholar
[169]	Volpin F., Badeti U., Wang C., et al. (2020). Urine treatment on the international space station: Current practice and novel approaches. Membranes 10:327. DOI:10.3390/membranes10110327 View in Article CrossRef Google Scholar
[170]	Lambert S.E. and Randall D.G. (2019). Manufacturing bio-bricks using microbial induced calcium carbonate precipitation and human urine. Water res. 160:158−166. DOI:10.1016/j.watres.2019.05.069 View in Article CrossRef Google Scholar
[171]	Yang Y., Chu J., Cheng L., et al. (2022). Utilization of carbide sludge and urine for sustainable biocement production. J. Environ. Chem. Eng. 10:107443. DOI:10.1016/j.jece.2022.107443 View in Article CrossRef Google Scholar
[172]	Fang C. and Achal V. (2024). Enhancing carbon neutrality: A perspective on the role of microbially induced carbonate precipitation (MICP). Biogeotech. 2:100083. DOI:10.1016/j.bgtech.2024.100083 View in Article CrossRef Google Scholar
[173]	Xiao Y., Zhao C., Sun Y., et al. (2021). Compression behavior of MICP-treated sand with various gradations. Acta Geotech. 16:1391−1400. DOI:10.1007/s11440-020-01116-2 View in Article CrossRef Google Scholar
[174]	Wilpiszeski R.L., Aufrecht J.A., Retterer S.T., et al. (2019). Soil aggregate microbial communities: Towards understanding microbiome interactions at biologically relevant scales. Appl. Environ. Microbiol. 85:e00324−19. DOI:10.1128/AEM.00324-19 View in Article CrossRef Google Scholar
[175]	Azami M., Kazemi Z., Moazen S., et al. (2024). A comprehensive review of lunar-based manufacturing and construction. Prog. Aerosp. Sci. 150:101045. DOI:10.1016/j.paerosci.2024.101045 View in Article CrossRef Google Scholar
[176]	Chen Y., Hu S., Li J.H., et al. (2023). Chang’e-5 lunar samples shed new light on the Moon. The Innovation Geoscience 1:100014−1. DOI:10.59717/j.xinn-geo.2023.100014 View in Article CrossRef Google Scholar
[177]	Liu H., Xiao Y., Shi J., Cao B., et al. (2025). 3D printing lunar regolith simulant with microbial-carbonated magnesium oxide. Biogeotech. 100197. DOI: 10.1016/j.bgtech.2025.100197 View in Article Google Scholar
[178]	Gu J., Qian X., Liu Y., et al. (2024). Charging properties and particle dynamics of Chang’e-5 lunar sample in an external electric field. Engineering 42:267−277. DOI:10.1016/j.eng.2024.08.003 View in Article CrossRef Google Scholar
[179]	Dikshit R., Gupta N., Dey A., et al. (2022). Microbial induced calcite precipitation can consolidate martian and lunar regolith simulants. Plos one 17:e0266415. DOI:10.1371/journal.pone.0266415 View in Article CrossRef Google Scholar
[180]	Shi J.Q., Xiao Z., Xiao Y., et al. (2024) Bio-molding of lunar regolith with bio-carbonized magnesium oxide. Biogeotech. 3: 100159. DOI: 10.1016/j.bgtech.2024.100159 View in Article Google Scholar
[181]	Jiang N.J., Yoshioka H., Yamamoto K., et al. (2016). Ureolytic activities of a urease-producing bacterium and purified urease enzyme in the anoxic condition: Implication for subseafloor sand production control by microbially induced carbonate precipitation (MICP). Ecol. Eng. 90:96−104. DOI:10.1016/j.ecoleng.2016.01.073 View in Article CrossRef Google Scholar
[182]	Ng S. and Chu J. (2024). Frozen enzyme EICP method for more effective soil improvement. Acta Geotech. 19:7117−7124. DOI:10.1007/s11440-024-02348-2 View in Article CrossRef Google Scholar
[183]	Kidanemariam T.G., Gebru K.A. and Kidane Gebretinsae H. (2024). A mini review of enzyme-induced calcite precipitation (EICP) technique for eco-friendly bio-cement production. Environ. Sci. Pollut. Res. Int. 31:16206−16215. DOI:10.1007/s11356-023-31555-9 View in Article CrossRef Google Scholar
[184]	Ahenkorah I., Rahman M.M., Karim M R., et al. (2021). A review of enzyme induced carbonate precipitation (EICP): The role of enzyme kinetics. Sustain. Chem. 2:92−114. DOI:10.3390/suschem2010007 View in Article CrossRef Google Scholar
[185]	Li C., Li S., Xing J., Gao Y., et al. (2025). On-site test of fixed mobile sand dunes using combined technology of sand plants and EICP in the Ulanbuh Desert, China. Acta Geotech. 20:1921−1934. DOI:10.1007/s11440-024-02524-4 View in Article CrossRef Google Scholar
[186]	Madusanka C., Udayanga D., Nilmini R., et al. (2024). A review of recent advances in fungal mycelium based composites. Discover Mater. 4:13. DOI:10.1007/s43939-024-00084-8 View in Article CrossRef Google Scholar
[187]	Elsacker E., Vandelook, ., Van Wylick A., et al. (2020). A comprehensive framework for the production of mycelium-based lignocellulosic composites. Sci. Total Environ. 725:138431. DOI:10.1016/j.scitotenv.2020.138431 View in Article CrossRef Google Scholar
[188]	Zhang X., Hu J., Fan X., et al. (2022). Naturally grown mycelium-composite as sustainable building insulation materials. J. Clean. Prod. 342:130784. DOI:10.1016/j.jclepro.2022.130784 View in Article CrossRef Google Scholar
[189]	Bonga K.B., Bertolacci L., Contardi M., et al. (2024). Mycelium agrowaste‐bound biocomposites as thermal and acoustic insulation materials in building construction. macromol. Mater. Eng. 309:2300449. DOI:10.1002/mame.202300449 View in Article CrossRef Google Scholar
[190]	Maximino C. Ongpeng J., Inciong E., et al. (2020). Using waste in producing bio-composite mycelium bricks. Appl. Sci. 10:5303. DOI:10.3390/app10155303 View in Article CrossRef Google Scholar
[191]	Viles E., Heyneman E., Lin S., et al. (2025). Mycelium as a scaffold for biomineralized engineered living materials. Cell Rep. Phys. Sci. 6:102517. DOI:10.1016/j.xcrp.2025.102517 View in Article CrossRef Google Scholar
[192]	Heveran C.M., Williams S.L., Qiu J., et al. (2020). Biomineralization and successive regeneration of engineered living building materials. Matter 2:481−494. DOI:10.1016/j.matt.2019.11.016 View in Article CrossRef Google Scholar
[193]	Roberts A.D., Whittall D.R., Breitling R., et al. (2021). Blood, sweat, and tears: Extraterrestrial regolith biocomposites with in vivo binders. Mater. Today Bio. 12:100136. DOI:10.1016/j.mtbio.2021.100136 View in Article CrossRef Google Scholar
[194]	Sauer R.L. (1985). Metabolic support for a lunar base. In lunar bases and space activities of the 21st century. https://ntrs.nasa.gov/citations/19860045375 View in Article Google Scholar
[195]	Jacobson T.A., Kler J.S., Hernke M.T. et al. (2019). Direct human health risks of increased atmospheric carbon dioxide. Nat. Sustain. 2:691−701. DOI:10.1038/s41893-019-0323-1 View in Article CrossRef Google Scholar
[196]	Horneck G., Facius R., Reichert M., et al. (2006) HUMEX, a study on the survivability and adaptation of humans to long-duration exploratory missions, part II: Missions to Mars. Adv. Space Res. 38: 752-759. DOI: 10.1016/j.asr.2005.06.072. View in Article Google Scholar
[197]	Keller R., Goli K., Porter W., et al. (2023). Cyanobacteria and algal-based biological life support system (BLSS) and planetary surface atmospheric revitalizing bioreactor brief concept review. Life 13:816. DOI:10.3390/life13030816 View in Article CrossRef Google Scholar
[198]	Kerner M., Wolff T. and Brinkmann T. (2024). Efficient supply with carbon dioxide from flue gas during large scale production of microalgae: A novel approach for bioenergy facades. Bioresource Technol. 391:129917. DOI:10.1016/j.biortech.2023.129917 View in Article CrossRef Google Scholar
[199]	Wagner I., Braun M., Slenzka K., et al. (2016). Photobioreactors in life support systems. Adv. Biochem. Eng. Biotechnol. 153:143−184. DOI:10.1007/10_2015_327 View in Article CrossRef Google Scholar
[200]	Gan F. and Bryant D.A. (2015). Adaptive and acclimative responses of cyanobacteria to far‐red light. Environ. Microbiol. 17:3450−3465. DOI:10.1111/1462-2920.12992 View in Article CrossRef Google Scholar
[201]	Salisbury F.B., Gitelson J.I. and Lisovsky G.M. (1997). Bios-3: Siberian experiments in bioregenerative life support.Attempts to purify air and grow food for space exploration in a sealed environment began in 1972. BioScience. 47: 575-585. DOI:10.2307/1313164 View in Article Google Scholar
[202]	Detrell G., Keppler J., Helisch H., et al. (2020). PBR@ LSR: The algae-based photobioreactor experiment at the ISS–operations and results. 2020 international conference on environmental systems. https://ttu-ir.tdl.org/handle/2346/86331 View in Article Google Scholar
[203]	Ellery A. (2021). Supplementing closed ecological life support systems with in-situ resources on the moon. Life 11:770. DOI:10.3390/life11080770 View in Article CrossRef Google Scholar
[204]	Ewert M.K., Drysdale A.E., Levri J.A. et al. (2002). Advanced life support requirements, assumptions and reference missions. AE technical paper. No. 2002-01-2480. DOI:10.4271/2002-01-2480 View in Article Google Scholar
[205]	Pickett M.T., Roberson L.B., Calabria J.L., et al. (2020). Regenerative water purification for space applications: Needs, challenges, and technologies towards' closing the loop. Life Sci. Space Res. 24:64−82. DOI:10.1016/j.lssr.2019.10.002 View in Article CrossRef Google Scholar
[206]	Espinosa-Ortiz E.J., Gerlach R., Peyton B.M., et al. (2023). Biofilm reactors for the treatment of used water in space: Potential, challenges, and future perspectives. Biofilm. 6:100140. DOI:10.1016/j.bioflm.2023.100140 View in Article CrossRef Google Scholar
[207]	Tang Y., Dong W., Ai W., et al. (2021). Design and establishment of a large-scale controlled ecological life-support system integrated experimental platform. Life Sci. Space Res. 31:121−130. DOI:10.1016/j.lssr.2021.08.001 View in Article CrossRef Google Scholar
[208]	Llorente B., Williams T.C., Goold H.D., et al. (2022). Harnessing bioengineered microbes as a versatile platform for space nutrition. Nat. Commun. 13:6177. DOI:10.1038/s41467-022-33974-7 View in Article CrossRef Google Scholar
[209]	Janssen M., Wijffels R.H. and Barbosa M.J. (2022). Microalgae based production of single-cell protein. Curr. Opin. Biotech. 75:102705. DOI:10.1016/j.copbio.2022.102705 View in Article CrossRef Google Scholar
[210]	Kumar B.R., Deviram G., Mathimani T., et al. (2019). Microalgae as rich source of polyunsaturated fatty acids. Biocatal. Agric. Biotechnol. 17:583−588. DOI:10.1016/j.bcab.2019.01.017 View in Article CrossRef Google Scholar
[211]	Coulombier N., Jauffrais T. and Lebouvier, N. (2021). Antioxidant compounds from microalgae: A review. Mar. Drugs. 19:549. DOI:10.3390/md19100549 View in Article CrossRef Google Scholar
[212]	Williamson E., Ross I.L., Wall B.T., et al. (2024). Microalgae: Potential novel protein for sustainable human nutrition. Trends Plant Sci. 29:370−382. DOI:10.1016/j.tplants.2023.08.006 View in Article CrossRef Google Scholar
[213]	Sharma P. and Nuri S.M. (2019). Nutrient recovery and microbial diversity in human urine fed microbial fuel cell. Water Sci. Technol. 79:718−730. DOI:10.2166/wst.2019.089 View in Article CrossRef Google Scholar
[214]	Oishi W., Vinnerås B. and Sano D. (2023). Resource recovery technologies as microbial risk barriers: Towards safe use of excreta in agriculture. Environ. Sci.: Water Res. Technol. 9:1008−1029. DOI:10.1039/D2EW00832G View in Article CrossRef Google Scholar
[215]	Caballero P., Macías-Benítez S., Revilla E., et al. (2020). Effect of subtilisin, a protease from Bacillus sp., on soil biochemical parameters and microbial biodiversity. Eur. J. Soil Biol. 101:103244. DOI:10.1016/j.ejsobi.2020.103244 View in Article CrossRef Google Scholar
[216]	Busato J.G., Lima L.S., Aguiar N.O., et al. (2012). Changes in labile phosphorus forms during maturation of vermicompost enriched with phosphorus-solubilizing and diazotrophic bacteria. Bioresource Technol. 110:390−395. DOI:10.1016/j.biortech.2012.01.126 View in Article CrossRef Google Scholar
[217]	Lee H., Diao J., Tian Y., et al. (2025). Developing an alternative medium for in-space biomanufacturing. Nat. Commun. 16:728. DOI:10.1038/s41467-025-56088-2 View in Article CrossRef Google Scholar
[218]	Verbeelen T., Leys N., Ganigué R., et al. (2021). Development of nitrogen recycling strategies for bioregenerative life support systems in space. Front. Microbiol. 12:700810. DOI:10.3389/fmicb.2021.700810 View in Article CrossRef Google Scholar
[219]	Fu Y., Li L., Xie B., et al. (2016). How to establish a bioregenerative life support system for long-term crewed missions to the moon or Mars. Astrobiology 16:925−936. DOI:10.1089/ast.2016.1477 View in Article CrossRef Google Scholar
[220]	Fu Y., Liu H., Liu D. et al. (2025). A case for supporting human long-term survival on the moon: “Lunar Palace 365” mission. Acta Astronaut. 228:131−140. DOI:10.1016/j.actaastro.2024.12.002 View in Article CrossRef Google Scholar
[221]	Kyazze G. (2020). Four ways microbial fuel cells might revolutionise electricity production in the future. The Conversation. https://theconversation.com/four-ways-microbial-fuel-cells-might-revolutionise-electricity-production-in-the-future-152184 View in Article Google Scholar
[222]	Dotson B., Valencia D.S., Millwater C., et al. (2024). Cohesion and shear strength of compacted lunar and Martian regolith simulants. Icarus. 411:115943. DOI:10.1016/j.icarus.2024.115943 View in Article CrossRef Google Scholar
[223]	Xi B., Jiang M., Mo P., et al. (2024). Bearing capacity of lunar soil ground under extraterrestrial environmental effects. Comp. Geotech. 165:105923. DOI:10.1016/j.compgeo.2023.105923 View in Article CrossRef Google Scholar
[224]	Zhang K., Tang C.S., Jiang N.J., et al. (2023). Microbial-induced carbonate precipitation (MICP) technology: A review on the fundamentals and engineering applications. Environ. Earth Sci. 82:229. DOI:10.1007/s12665-023-10899-y View in Article CrossRef Google Scholar
[225]	Van Paassen L.A., Ghose R., van der Linden, et al. (2010). Quantifying biomediated ground improvement by ureolysis: Large-scale biogrout experiment. J. Geotech. Geoen. 136:1721−1728. DOI:10.1061/(ASCE)GT.1943-5606.0000382 View in Article CrossRef Google Scholar
[226]	Van Paassen, L. A. (2011). Bio-mediated ground improvement: From laboratory experiment to pilot applications. Han J, Alzamora D.E. (eds). Geo-Frontiers 2011: Advances in geotechnical engineering, pp: 4099-4108. DOI:10.1061/41165(397)419 View in Article Google Scholar
[227]	Ghasemi P. and Montoya B.M. (2022). Field implementation of microbially induced calcium carbonate precipitation for surface erosion reduction of a coastal plain sandy slope. J. Geotech. Geoen. 148:04022071. DOI:10.1061/(ASCE)GT.1943-5606.0002836 View in Article CrossRef Google Scholar
[228]	Xiao Y., He X., Zaman M., et al. (2022). Review of strength improvements of biocemented soils. Int. J. Geomech. 22:03122001. DOI:10.1061/(ASCE)GM.1943-5622.0002565 View in Article CrossRef Google Scholar
[229]	Gao X., Han Z., Zhao Y., et al. (2024). Interaction of microorganisms with carbonates from the micro to the macro scales during sedimentation: Insights into the early stage of biodegradation. J. Environ. Manage. 356:120714. DOI:10.1016/j.jenvman.2024.120714 View in Article CrossRef Google Scholar
[230]	Jongvivatsakul P., Janprasit K., Nuaklong P., et al. (2019). Investigation of the crack healing performance in mortar using microbially induced calcium carbonate precipitation (MICP) method. Constr. Build. Mater. 212:737−744. DOI:10.1016/j.conbuildmat.2019.04.035 View in Article CrossRef Google Scholar
[231]	Zhang Y.S., Liu Y., Sun X. et al. (2024). Application of microbially induced calcium carbonate precipitation (MICP) technique in concrete crack repair: A review. Constr. Build. Mater. 411:134313. DOI:10.1016/j.conbuildmat.2023.134313 View in Article CrossRef Google Scholar
[232]	Reda M.A. and Chidiac S.E. (2022). Performance of capsules in self-healing cementitious material. Materis 15:7302. DOI:10.3390/ma15207302 View in Article CrossRef Google Scholar
[233]	Gupta N., Kulkarni R., Naik A.R., et al. (2025). Bacterial bio-cementation can repair space bricks. Front. Space Technol. 6:1550526. DOI:10.3389/frspt.2025.1550526 View in Article CrossRef Google Scholar
[234]	Atmakuri A., Yadav B., Tiwari B., et al. (2024). Nature’s architects: A comprehensive review of extracellular polymeric substances and their diverse applications. Waste Dispos. Sustain. Energy 6:529−551. DOI:10.1007/s42768-024-00205-2 View in Article CrossRef Google Scholar
[235]	Chevrier V.F., Hanley J. and Altheide T.S. (2009). Stability of perchlorate hydrates and their liquid solutions at the Phoenix landing site, Mars. Geophys. Res. Lett. 36:L10202. DOI:10.1029/2009GL037497 View in Article CrossRef Google Scholar
[236]	Hecht M.H., Kounaves S.P., Quinn R.C., et al. (2009) Detection of perchlorate and the soluble chemistry of Martian soil at the Phoenix Lander Site. Science 325: 64–67. DOI: 10.1126/science.1172466 View in Article Google Scholar
[237]	Rzymski P., Poniedziałek B., Hippmann N., et al. (2022). Screening the survival of cyanobacteria under perchlorate stress. Potential implications for Mars in situ resource utilization. Astrobiology 22:672−684. DOI:10.1089/ast.2021.0100 View in Article CrossRef Google Scholar
[238]	Rzymski P., Losiak A., Heinz J., et al. (2024). Perchlorates on Mars: Occurrence and implications for putative life on the Red Planet. Icarus 421:116246. DOI:10.1016/j.icarus.2024.116246 View in Article CrossRef Google Scholar
[239]	Fagliarone C., Fernandez B.G., Di Stefano G., et al. (2024). Insights into the chaotropic tolerance of the desert cyanobacterium Chroococcidiopsis sp. 029 (Chroococcidiopsales, cyanobacteria). J. Phycol. 60: 185-194. DOI: 10.1111/jpy.13414 View in Article Google Scholar
[240]	Díaz-Rullo J., Rodríguez-Valdecantos G., Torres-Rojas F. et al. (2021). Mining for perchlorate resistance genes in microorganisms from sediments of a hypersaline pond in Atacama Desert, Chile. Front. Microbiol. 12:723874. DOI:10.3389/fmicb.2021.723874 View in Article CrossRef Google Scholar
[241]	Misra G., Smith W., Garner M., et al. (2021). Potential biological remediation strategies for removing perchlorate from Martian regolith. New Space 9:217−227. DOI:10.1089/space.2020.0055 View in Article CrossRef Google Scholar
[242]	Ruff S.E., Schwab L., Vidal E., et al. (2024). Widespread occurrence of dissolved oxygen anomalies, aerobic microbes, and oxygen-producing metabolic pathways in apparently anoxic environments. FEMS Microbiol. Ecol. 100:fiae132. DOI:10.1093/femsec/fiae132 View in Article CrossRef Google Scholar
[243]	Meylani V., Santri D.J. and Surahman E. (2024). Microbial electrochemical technologies: Different configurations, electrodes and working principle/microbial electrochemical eechnologies—working principle and design of biocathode. Selvasembian R., Mal J., Das S., Verma D.K., Anastopoulos I. (eds). Emerging trends in microbial electrochemical technologies for sustainable mitigation of water resources contamination (Springer, Cham.), pp:63-81. DOI: 10.1007/978-3-031-74636-9_3 View in Article Google Scholar
[244]	Li X., Bai W., Yang Q., et al. (2024). The extremotolerant desert moss Syntrichia caninervis is a promising pioneer plant for colonizing extraterrestrial environments. The Innovation 5:100657. DOI:10.1016/j.xinn.2024.100657 View in Article CrossRef Google Scholar
[245]	Sun F., Xiao B., Kidron G.J., et al. (2024). Biocrusts critical regulation of soil water vapor transport (diffusion, sorption, and late‐stage evaporation) in drylands. Water Resour Res. 60:e2023WR036520. DOI:10.1029/2023WR036520 View in Article CrossRef Google Scholar
[246]	Verseux C., Heinicke C., Ramalho T.P., et al. (2021). A low-pressure, N₂/CO₂ atmosphere is suitable for cyanobacterium-based life-support systems on Mars. Front microbiol. 12:611798. DOI:10.3389/fmicb.2021.611798 View in Article CrossRef Google Scholar
[247]	Figueira J., Koch S., Müller D.W. et al. (2025). Biomining of lunar regolith simulant EAC-1 A with the fungus Penicillium simplicissimum. Fungal Biol. Biotechnol. 12:8. DOI:10.1186/s40694-025-00201-z View in Article CrossRef Google Scholar
[248]	Santomartino R., Blanco G.R., Gudgeon A., et al. (2024). Testing microbial biomining from asteroidal material onboard the International Space Station. bioRxiv 2024-01. DOI: 10.1101/2024.01.13.575412 View in Article Google Scholar
[249]	Kruyer N.S., Realff M.J., Sun W., et al. (2021). Designing the bioproduction of Martian rocket propellant via a biotechnology-enabled in situ resource utilization strategy. Nat. Commun. 12:6166. DOI:10.1038/s41467-021-26393-7 View in Article CrossRef Google Scholar
[250]	Rampelotto P.H. (2010). Resistance of microorganisms to extreme environmental conditions and its contribution to astrobiology. Sustainability. 2:1602−1623. DOI:10.3390/su2061602 View in Article CrossRef Google Scholar
[251]	Putatunda C., Solanki P., Pathania S., et al. (2023). Screening strategies: . Bhatt A.K., Bhatia R.K. and Bhalla T.C. (eds). Basic biotechniques for bioprocess and bioentrepreneurship (Academic Press), pp: 23-46. DOI: 10.1016/B978-0-12-816109-8.00002-7 View in Article Google Scholar
[252]	Ott E., Fuchs F.M., Moeller R., et al. (2019). Molecular response of Deinococcus radiodurans to simulated microgravity explored by proteometabolomic approach. Sci. Rep. 9:18462. DOI:10.1038/s41598-019-54742-6 View in Article CrossRef Google Scholar
[253]	Mohseni P. and Ghorbani A. (2024). Exploring the synergy of artificial intelligence in microbiology: Advancements, challenges, and future prospects. Comput. Struct. Biotechnology Rep. 1:100005. DOI:10.1016/j.csbr.2024.100005 View in Article CrossRef Google Scholar
[254]	Choi S.R., Lee M. (2023). Transformer architecture and attention mechanisms in genome data analysis: A comprehensive review. Biology 12:1033. DOI:10.3390/biology12071033 View in Article CrossRef Google Scholar
[255]	Zhu M., Wang Q., Mu H., et al. (2023). A fitness trade-off between growth and survival governed by Spo0A-mediated proteome allocation constraints in Bacillus subtilis. Sci Adv. 9:eadg9733. DOI:10.1126/sciadv.adg9733 View in Article CrossRef Google Scholar
[256]	SESRI: Bringing space to earth (2020). Nature. DOI:10.1038/d42473-020-00198-6. (2023-10-01). https://www.nature.com/articles/d42473-020-00198-6 View in Article Google Scholar
[257]	Zhao C., Xiao Y., He X., et al. (2025). Influence of injection methods on bio-mediated precipitation of carbonates in fracture-mimicking microfluidic chip. Géotechnique 75:153−165. DOI:10.1680/jgeot.23.00155 View in Article CrossRef Google Scholar
[258]	Xiao Y., He X., Stuedlein A.W., et al. (2022). Crystal growth of micp through microfluidic chip tests. J. Geotech. Geoenviron. 148:06022002. DOI:10.1061/(ASCE)GT.1943-5606.0002756 View in Article CrossRef Google Scholar
[259]	Krakos A. (2024). Lab-on-chip technologies for space research—current trends and prospects. Microchimica Acta 191:31. DOI:10.1007/s00604-023-06084-4 View in Article CrossRef Google Scholar
[260]	Vandaele A.C., Aoki S., Bauduin S., et al. (2024). Composition and chemistry of the Martian atmosphere as observed by Mars express and ExoMars trace gas orbiter. Space Sci Rev. 220:75. DOI:10.1007/s11214-024-01109-7 View in Article CrossRef Google Scholar
[261]	Schorghofer N., Williams J.P., Martinez‐Camacho, et al. (2021). Carbon dioxide cold traps on the moon. Geophys. Res. Lett. 48:e2021GL095533. DOI:10.1029/2021GL095533 View in Article CrossRef Google Scholar

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Li S., Gan Y., Zhou C., et al. (2026). Extraterrestrial bioconstruction technology system: Bridging space station applications and deep-space missions. The Innovation Life 4:100193. https://doi.org/10.59717/j.xinn-life.2026.100193

Li S., Gan Y., Zhou C., et al. (2026). Extraterrestrial bioconstruction technology system: Bridging space station applications and deep-space missions. The Innovation Life 4:100193. https://doi.org/10.59717/j.xinn-life.2026.100193

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