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Targeting GSDMD-mediated pyroptosis: An AI-guided peptide discovery

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  • [1] Min R., Bai Y., Wang N., et al. (2025). Gasdermins in pyroptosis, inflammation, and cancer. Trends Mol. Med. 31:860–875. DOI: 10.1016/j.molmed.2025.04.003

    View in Article Google Scholar

    [2] Ding J., Wang K., Liu W., et al. (2016). Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535: 111-116. DOI:10.1038/nature18590

    View in Article Google Scholar

    [3] Shi J., Zhao Y., Wang K., et al. (2015). Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526:660-665. DOI:10.1038/nature15514

    View in Article Google Scholar

    [4] Kayagaki N., Stowe IB., Lee BL., et al. (2015). Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526:666-671. DOI:10.1038/nature15541

    View in Article Google Scholar

    [5] Sun J., Yang J., Tao J., et al. (2025). Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response. Nat. Immunol. 26:1660-1672. DOI:10.1038/s41590-025-02280-x

    View in Article Google Scholar

  • Cite this article:

    Wang W., Liang Q. and Wang C. (2026). Targeting GSDMD-mediated pyroptosis: An AI-guided peptide discovery. The Innovation Life 4:100194. https://doi.org/10.59717/j.xinn-life.2026.100194
    Wang W., Liang Q. and Wang C. (2026). Targeting GSDMD-mediated pyroptosis: An AI-guided peptide discovery. The Innovation Life 4:100194. https://doi.org/10.59717/j.xinn-life.2026.100194

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