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GSDMD-NT’s pan-membrane blitz on the liver

  • 1.

    State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Immunity and Infection, Shanghai Institute of Materia Medica, CAS, Shanghai 200031, China

  • 2.

    University of Chinese Academy of Sciences, Beijing 100049, China

  • 3.

    Shanghai Academy of Natural Sciences (SANS), Shanghai 200031, China

  • 4.

    These authors contributed equally

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  • Corresponding author: xingliu@ips.ac.cn
  • Received Date:  May 07, 2026
    Accepted Date:  July 06, 2026
    Published Online:  July 07, 2026
The Innovation Life  https://doi.org/10.59717/j.xinn-life.2026.100237  |  Cite this article
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  • [1] Huang Y., Lin L., Yang G., et al. (2025). Pan-membrane pyroptosis of liver induced by gasdermin-encoding mRNAs. Natl. Sci. Rev. 13:nwaf452. DOI:10.1093/nsr/nwaf452

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    [2] Bai Y., Pan Y. and Liu X. (2025). Mechanistic insights into gasdermin-mediated pyroptosis. Nat. Rev. Mol. Cell Biol. 26:501−521. DOI:10.1038/s41580-025-00837-0

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    [3] Min R., Bai Y., Wang N., et al. (2025). Gasdermins in pyroptosis, inflammation, and cancer. Trends Mol. Med. 31:860-875. DOI:10.1016/j.molmed.2025.04.003

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    [4] Miao R., Jiang C., Chang W., et al. (2023). Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis. Immunity 56:2523-2541.e2528. DOI:10.1016/j.immuni.2023.10.004

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    [5] Fontana P., Du G., Zhang Y., et al. (2024). Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity. Cell 187:6165−6181.e6122. DOI:10.1016/j.cell.2024.08.007

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  • Cite this article:

    Min R. and Liu X. (2026). GSDMD-NT’s pan-membrane blitz on the liver. The Innovation Life 4:100237. https://doi.org/10.59717/j.xinn-life.2026.100237
    Min R. and Liu X. (2026). GSDMD-NT’s pan-membrane blitz on the liver. The Innovation Life 4:100237. https://doi.org/10.59717/j.xinn-life.2026.100237

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