Constitutionally isomeric antimicrobial peptides: Candidates for antibacterial treatment with morphology-dependent efficacy
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ABSTRACT
Antimicrobial peptides (AMPs) have been used as a substitute for antibiotics due to the special antibacterial mechanism synergistically driven by their positive surface charge and hydrophobic domains. However, the relationship between the amino acid sequence and the antimicrobial efficacy remains unclear. In this review, we summarized the recent advances in constitutionally isomeric AMPs, which regulated the antibacterial efficiency by changing the position of certain amino acid residues. We also briefly illustrated the application of constitutionally isomeric peptides templated with inorganic nanoparticles in antibacterial treatments. At the end, we provided future outlooks and potential challenges faced in this research area. We hope that our efforts could bring more insight into the rational design of AMPs and how subtle changes in peptide sequence would affect the resultant bioactivity. -
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REFERENCES
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Lu Y., Shao Y. and Wang Y. (2025). Constitutionally isomeric antimicrobial peptides: Candidates for antibacterial treatment with morphology-dependent efficacy. The Innovation Materials 3:100155. https://doi.org/10.59717/j.xinn-mater.2025.100155
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Lu Y., Shao Y. and Wang Y. (2025). Constitutionally isomeric antimicrobial peptides: Candidates for antibacterial treatment with morphology-dependent efficacy. The Innovation Materials 3:100155. https://doi.org/10.59717/j.xinn-mater.2025.100155
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Figure 1.
Molecular structures, TEM images of
