A biomimetic breakthrough in glycinate aldol reaction: Enzyme-inspired efficient access to chiral β-hydroxy-α-amino acids
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REFERENCES
[1] Dückers N., Baer K., Simon S., et al. (2010). Threonine aldolases—screening, properties and applications in the synthesis of non-proteinogenic β-hydroxy-α-amino acids. Appl. Microbiol. Biotechnol. 88:409. DOI:10.1007/s00253-010-2751-8 [2] Liang H., Ren P., Wang L., et al. (2025). Asymmetric biomimetic aldol reaction of glycinate enables highly efficient synthesis of chiral β-hydroxy-α-amino acid derivatives. Nat. Catal. 8:668. DOI:10.1038/s41929-025-01364-z [3] Breslow R. (1995). Biomimetic Chemistry and Artificial Enzymes: Catalysis by Design, Acc. Chem. Res. 28:146. DOI:10.1021/ar00051a008 [4] Xiao X. and Zhao B. (2023). Vitamin B6-based biomimetic asymmetric catalysis. Acc. Chem. Res. 56:1097. DOI:10.1021/acs.accounts.3c00053. [5] Xiao X., Xu K., Gao Z.-H., et al. (2023). Biomimetic asymmetric catalysis. Sci. China Chem. 66:1553. DOI:10.1007/s11426-023-1578-y -
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Du H. (2025). A biomimetic breakthrough in glycinate aldol reaction: Enzyme-inspired efficient access to chiral β-hydroxy-α-amino acids. The Innovation Materials 4:100182. https://doi.org/10.59717/j.xinn-mater.2026.100182
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Du H. (2025). A biomimetic breakthrough in glycinate aldol reaction: Enzyme-inspired efficient access to chiral β-hydroxy-α-amino acids. The Innovation Materials 4:100182. https://doi.org/10.59717/j.xinn-mater.2026.100182
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Figure 1.
Mechanism diagram of biomimetic glycinate aldol reaction.
