The associations of energy adjusted dietary inflammatory index with brain structure and cognitive function

Dashan Zheng; Bingting Zhuo; Guzhengyue Zheng; Junjie Hua; Junguo Zhang; Chongjian Wang; Yuhua Wang; Zilong Zhang; Hualiang Lin

doi:10.59717/j.xinn-med.2023.100036

The Innovation Medicine > 2023 Vol. 1 > No. 3 > 100036

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The associations of energy adjusted dietary inflammatory index with brain structure and cognitive function

1.
Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
2.
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China
3.
These authors contributed equally

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Corresponding author: linhualiang@mail.sysu.edu.cn
Received Date: August 05, 2023

Accepted Date: November 16, 2023

Published Online: November 22, 2023

The Innovation Medicine 1(3), https://doi.org/10.59717/j.xinn-med.2023.100036 | Cite this article

GRAPHICAL ABSTRACT

GRAPHICAL ABSTRACT

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PUBLIC SUMMARY

PUBLIC SUMMARY
1. Higher dietary inflammatory index links to more severe brain structure abnormalities.
  
  Brain structure abnormalities mediate the “inflammatory diet-cognition” association.
  
  Controlling inflammatory diet may protect rain structure and cognitive function.

ABSTRACT

ABSTRACT

Limited research exists on the mediating effect of brain structure in the association between dietary inflammatory index (DII) and cognitive impairment. To address this issue, this analysis utilized data from a cohort of 15,526 participants in the UK Biobank who underwent brain magnetic resonance imaging (MRI) during 2014-2020. We assessed the associations between energy adjusted DII (E-DII, calculated by 28 components) and cognitive function (represented by fluid intelligence scores, FIS), as well as the brain structures, including total brain volume (TBV), white matter volume (WMV), white matter hyperintensities volume (WMHV) and grey matter volume (GMV) of 76 cortices, 14 subcortices and 28 cerebellum regions. We further estimated the mediation effects of brain structures on the association between E-DII and cognitive function. From this analysis, we observed that higher E-DII was associated with reduced TBV, GMV, WMV, FIS and higher WMHV. Each one unit increase in E-DII was associated with 0.025(0.007, 0.041) FIS decrease, 937.93 mm³ (95% CI: 494.48.07, 1,381.38) GMV decrease, 675.02 mm³ (95% CI: 279.02, 1,071.02) WMV decrease and 93.80 mm³ (95% CI: 41.45, 146.14) WMHV increase. Furthermore, GMV, WMHV, WMV were found to significantly mediate the association between E-DII and cognitive function, accounting for 21.82% (95% CI: 11.26%, 33.24%), 19.19% (95% CI: 8.52%, 30.63%) and 4% (95% CI: 1.31%, 7.99%). These results indicated that controlling of inflammatory diet could prevent brain structures abnormalities and might reduce the risk of cognitive impairment.

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Zheng D., Zhuo B., Zheng G., et al., (2023). The associations of energy adjusted dietary inflammatory index with brain structure and cognitive function. The Innovation Medicine 1(3), 100036. https://doi.org/10.59717/j.xinn-med.2023.100036

Zheng D., Zhuo B., Zheng G., et al., (2023). The associations of energy adjusted dietary inflammatory index with brain structure and cognitive function. The Innovation Medicine 1(3), 100036. https://doi.org/10.59717/j.xinn-med.2023.100036

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The associations of energy adjusted dietary inflammatory index with brain structure and cognitive function

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The associations of energy adjusted dietary inflammatory index with brain structure and cognitive function

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