Stem cell niches functionalized strategies for organ regeneration and manufacturing

Huan Liu; Lei Hu; Dake Zhang; Xiaogang Wang; Songlin Wang

doi:10.59717/j.xinn-med.2023.100037

The Innovation Medicine > 2023 Vol. 1 > No. 3 > 100037

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Stem cell niches functionalized strategies for organ regeneration and manufacturing

1.
Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China
2.
Research Units of Tooth Development and Regeneration, Chinese Academy of Medical Sciences, Beijing 100069, China
3.
Department of Prosthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China
4.
Key Laboratory of Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University, Beijing 100191, China
5.
Immunology Research Center for Oral and Systemic Health, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
6.
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
7.
Laboratory for Oral and General Health Integration and Translation, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
8.
These authors contributed equally

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Corresponding authors: slwang@ccmu.edu.cn (S.W.); xiaogangwang@buaa.edu.cn (X.W.)
Received Date: July 18, 2023

Accepted Date: November 16, 2023

Published Online: November 22, 2023

The Innovation Medicine 1(3), https://doi.org/10.59717/j.xinn-med.2023.100037 | Cite this article

GRAPHICAL ABSTRACT

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PUBLIC SUMMARY

PUBLIC SUMMARY
1. Stem cell niches determine stem cells fate and homeostasis.
  
  Stem cell niches provide opportunities for organ regeneration.
  
  Stem cell niches-functionalized strategies have been emerging.

ABSTRACT

ABSTRACT

Organ regeneration and manufacturing are promising new research directions in the life sciences. Stem cells and their niches, which exist in most adult organs, play a central role in organ development, homeostasis, and regeneration. Although considerable advances have been made in stem cell-mediated organ regeneration and manufacturing in recent decades, their clinical effectiveness remains unsatisfactory. Stem cell niches comprise a dynamic microenvironment that supports stem cells throughout their lifetime and are critical to stem cell fate. Based on recent research on stem cell niches, tremendous progress has been made in organ regeneration and manufacturing in vivo and in vitro. In this review, we discuss recent advances in the composition and function of stem cell niches during regeneration. We also discuss stem cell niche remodeling using cell-cell interaction, extracellular matrix (ECM) reconstruction, cell-ECM interaction, and key signaling-based niche strategies to promote endogenous tooth, gastrointestinal tract, and liver regeneration and its application in organoids and organoid-on-chip construction.

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Liu H, Hu L, Zhang D, et al., (2023). Stem cell niches functionalized strategies for organ regeneration and manufacturing. The Innovation Medicine 1(3), 100037. https://doi.org/10.59717/j.xinn-med.2023.100037

Liu H, Hu L, Zhang D, et al., (2023). Stem cell niches functionalized strategies for organ regeneration and manufacturing. The Innovation Medicine 1(3), 100037. https://doi.org/10.59717/j.xinn-med.2023.100037

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