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The Innovation Medicine > 2023 Vol. 1 > No. 3 > 100042
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Exposure to airborne PM2.5 chemical exposome increases heart rate of middle- and old-aged populations

  • 1.

    CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China

  • 2.

    National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China

  • 3.

    School of Public Health, Nanjing Medical University, Nanjing 211166, China

  • 4.

    School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China

  • 5.

    School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China

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The Innovation Medicine  1(3),  https://doi.org/10.59717/j.xinn-med.2023.100042  |  Cite this article
    GRAPHICAL ABSTRACT
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    • PUBLIC SUMMARY

    1. Mixed effects and key components of airborne PM2.5 chemical exposome are identified and quantified.

      Airborne PM2.5 chemical exposome can increase heart rate of middle- and old-aged populations.

      Several key industrial chemicals drive the overall effect of airborne PM2.5 chemical exposome.

      The cardiovascular hazards of airborne PM2.5 chemical exposome are highlighted.

    • ABSTRACT
  • Previous studies have rarely focused on the effects of industrial chemicals on heart rate. There is also a lack of epidemiological investigations to elucidate the mixture effects of complex components of fine particulate matter (PM2.5) on cardiovascular health and identify the key toxic components. Here, a population health-oriented methodology is established to quantify mixed effects of airborne PM2.5 chemical exposome and identify key components. This methodology was applied to a cross-sectional study to elucidate the mixture effect of industrial chemical components of PM2.5 on the heart rate of middle- and old-aged populations (including 373 people from seven Chinese cities) and further identify key chemical components for the effect. Exposure to seven groups of industrial chemicals, including phthalate esters (PAEs), adipate esters (AEs), benzothiazoles and benzotriazoles (BTHs & BTRs), benzophenones and benzoates (BZPs & BZAs), bisphenols (BPs), alkyl organophosphate esters (alkyl-OPEs) and aryl organophosphate esters (aryl-OPEs), was observed to significantly increase the heart rate of study participants. Seven chemicals, including dimethyl isophthalate (DMiP), di-iso-nonyl adipate (DiNA), 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV-328), ethyl-4-aminobenzoate (EAB), bisphenol F (BPF), triethyl phosphate (TEP) and tricresyl phosphate (TCrP), were identified as the key components driving the adverse effect on heart rate. Our study highlights the cardiovascular hazards of airborne PM2.5 chemical exposome.
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  • Cite this article:

    Sun Y., Wang M., Wang Y., et al., (2023). Exposure to airborne PM2.5 chemical exposome increases heart rate of middle- and old-aged populations. The Innovation Medicine 1(3), 100042. https://doi.org/10.59717/j.xinn-med.2023.100042
    Sun Y., Wang M., Wang Y., et al., (2023). Exposure to airborne PM2.5 chemical exposome increases heart rate of middle- and old-aged populations. The Innovation Medicine 1(3), 100042. https://doi.org/10.59717/j.xinn-med.2023.100042

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