Smoking’s Achilles heel demystified: Triggering persistent adaptive immunity by variability responses to immunogens
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[1] Saint-Andre, V., Charbit, B., Biton, A., et al. (2024). Smoking changes adaptive immunity with persistent effects. Nature 626: 827−835. DOI: 10.1038/s41586-023-06968-8. [2] Weeden, C.E., Gayevskiy, V., Marceaux, C., et al. (2023). Early immune pressure initiated by tissue-resident memory t cells sculpts tumor evolution in non-small cell lung cancer. Cancer Cell 41: 837−852.e836. DOI: 10.1016/j.ccell.2023.03.019. [3] Naik, S., and Fuchs, E. (2022). Inflammatory memory and tissue adaptation in sickness and in health. Nature 607: 249−255. DOI: 10.1038/s41586-022-04919-3. [4] Netea, M.G., Domínguez-Andrés, J., Barreiro, L.B., et al. (2020). Defining trained immunity and its role in health and disease. Nat. Rev. Immunol. 20: 375−388. DOI: 10.1038/s41577-020-0285-6. [5] Gonzales, K.A.U., Polak, L., Matos, I., et al. (2021). Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories. Science 374: eabh2444. DOI: 10.1126/science.abh2444. -
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Pan T., Huang Y., and Wu M. (2024). Smoking’s Achilles heel demystified: Triggering persistent adaptive immunity by variability responses to immunogens. The Innovation Medicine 2(3): 100078. https://doi.org/10.59717/j.xinn-med.2024.100078
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Pan T., Huang Y., and Wu M. (2024). Smoking’s Achilles heel demystified: Triggering persistent adaptive immunity by variability responses to immunogens. The Innovation Medicine 2(3): 100078. https://doi.org/10.59717/j.xinn-med.2024.100078
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Figure 1.
Different effects of smoking on innate immunity and adaptive immunity.
