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The Innovation Medicine > 2025 Vol. 3 > No. 3 > 100138
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Diabetes drug crosses over: Metformin emerges as novel therapeutic option for hematologic malignancies

  • 1.

    Medical Research Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, China

  • 2.

    Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, China

  • 3.

    Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao 266003, China

  • 4.

    Research Center for Environment and Female Reproductive Health, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China

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The Innovation Medicine  3(3),  https://doi.org/10.59717/j.xinn-med.2025.100138  |  Cite this article
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  • [1] Hosseini M., Voisin V., Chegini A., et al. (2025). Metformin reduces the competitive advantage of Dnmt3a(R878H) HSPCs. Nature 642:421−430. DOI:10.1038/s41586-025-08871-w

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    [2] Gozdecka M., Dudek M., Wen S., et al. (2025). Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis. Nature 642:431−441. DOI:10.1038/s41586-025-08980-6

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    [3] Yang Y., Lu X., Liu N., et al. (2024). Metformin decelerates aging clock in male monkeys. Cell 187:6358-6378 e6329. DOI:10.1016/j.cell.2024.08.021

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    [4] Agarwal P., Sampson A., Hueneman K., et al. (2025). Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1. Nature 642:201−211. DOI:10.1038/s41586-025-08938-8

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    [5] Pich O., Bernard E., Zagorulya M., et al. (2025). Tumor-infiltrating clonal hematopoiesis. N. Engl. J. Med. 392:1594−1608. DOI:10.1056/NEJMoa2413361

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  • Cite this article:

    Sun L., Dong B. and Zhang H. (2025). Diabetes drug crosses over: Metformin emerges as novel therapeutic option for hematologic malignancies. The Innovation Medicine 3:100138. https://doi.org/10.59717/j.xinn-med.2025.100138
    Sun L., Dong B. and Zhang H. (2025). Diabetes drug crosses over: Metformin emerges as novel therapeutic option for hematologic malignancies. The Innovation Medicine 3:100138. https://doi.org/10.59717/j.xinn-med.2025.100138

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