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The Innovation Medicine > 2025 Vol. 3 > No. 3 > 100149
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Stem cell-derived islets — significant progress amidst ongoing challenges for type 1 diabetes

  • 1.

    School of Biomedical Sciences, Hunan University, Changsha 410082, China

  • 2.

    Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

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  • Corresponding author: liuhaisong@hnu.edu.cn
  • Received Date:  June 26, 2025
    Accepted Date:  August 05, 2025
    Published Online:  August 08, 2025
The Innovation Medicine  3(3),  https://doi.org/10.59717/j.xinn-med.2025.100149  |  Cite this article
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  • [1] Reichman T.W., Markmann J.F., Odorico J., et al. (2025). Stem cell-derived, fully differentiated islets for type 1 diabetes. N. Engl. J. Med. Online ahead of print. DOI:10.1056/NEJMoa2506549

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    [2] Ramzy A., Thompson D.M., Ward-Hartstonge K.A., et al. (2021). Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes. Cell Stem Cell 28:2047−2061.e5. DOI:10.1016/j.stem.2021.10.003

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    [3] Keymeulen, B., De Groot, K., Jacobs-Tulleneers-Thevissen, D., et al. (2024). Encapsulated stem cell-derived beta cells exert glucose control in patients with type 1 diabetes. Nat. Biotechnol. 42:1507−1514. DOI:10.1038/s41587-023-02055-5

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    [4] Wang S., Du Y., Zhang B., et al. (2024). Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient. Cell 187:6152−6164.e18. DOI:10.1016/j.cell.2024.09.004

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    [5] Wu J., Li T., Guo M., et al. (2024). Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue. Cell Discov. 10:45. DOI:10.1038/s41421-024-00662-3

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  • Cite this article:

    Dong L., Cao X., Mi C., et al. (2025). Stem cell-derived islets — significant progress amidst ongoing challenges for type 1 diabetes. The Innovation Medicine 3:100149. https://doi.org/10.59717/j.xinn-med.2025.100149
    Dong L., Cao X., Mi C., et al. (2025). Stem cell-derived islets — significant progress amidst ongoing challenges for type 1 diabetes. The Innovation Medicine 3:100149. https://doi.org/10.59717/j.xinn-med.2025.100149

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