Advanced Search
Article Contents
ABOUT THIS ARTICLE
The Innovation Medicine > 2025 Vol. 3 > No. 4 > 100159
Next Article Previous Article
LETTER   Open Access     Cite

The RNA fusion landscape of human placentae and pre-eclampsia

  • 1.

    Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China

  • 2.

    Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen 518132, China

  • 3.

    Division of Life Science, Department of Chemical and Biological Engineering, and State Key Laboratory of Nervous System Disorders, Hong Kong University of Science and Technology, Hong Kong SAR 999077, China

  • 4.

    Shenzhen Maternity & Child Healthcare Hospital, Shenzhen 518028, China

  • 5.

    Shenzhen Medical Academy of Research and Translation, Shenzhen 518107, China

  • 6.

    School of Life Sciences, Westlake University, Hangzhou 310030, China

  • 7.

    School of Science, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China

  • 8.

    Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China

  • 9.

    Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China

  • 10.

    These authors contribute equally

    • Show all affliationsShow less
More Information
  • Corresponding author: sunkun@szbl.ac.cn
  • Received Date:  January 23, 2025
    Accepted Date:  September 17, 2025
    Published Online:  September 24, 2025
The Innovation Medicine  3(4),  https://doi.org/10.59717/j.xinn-med.2025.100159  |  Cite this article
    • FullText(HTML)
  • 加载中
    • REFERENCES
  • [1] Chappell L. C., Cluver C. A., Kingdom J., et al. (2021). Pre-eclampsia. Lancet 398:341−354. DOI:10.1016/S0140-6736(20)32335-7

    View in Article CrossRef Google Scholar

    [2] Zeisler H., Llurba E., Chantraine F., et al. (2016). Predictive value of the sFlt-1: PlGF ratio in women with suspected preeclampsia. N. Engl. J. Med. 374:13−22. DOI:10.1056/NEJMoa1414838

    View in Article CrossRef Google Scholar

    [3] Agrawal S., Shinar S., Cerdeira A. S., et al. (2019). Predictive performance of PlGF (placental growth factor) for screening preeclampsia in asymptomatic women: A systematic review and meta-analysis. Hypertension 74:1124−1135. DOI:10.1161/HYPERTENSIONAHA.119.13360

    View in Article CrossRef Google Scholar

    [4] Levine R. J., Lam C., Qian C., et al. (2006). Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N. Engl. J. Med. 355:992−1005. DOI:10.1056/NEJMoa055352

    View in Article CrossRef Google Scholar

    [5] Li H., Wang J., Mor G., et al. (2008). A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells. Science 321:1357−1361. DOI:10.1126/science.1156725

    View in Article CrossRef Google Scholar

    [6] Babiceanu M., Qin F., Xie Z., et al. (2016). Recurrent chimeric fusion RNAs in non-cancer tissues and cells. Nucleic Acids Res. 44:2859−2872. DOI:10.1093/nar/gkw032

    View in Article CrossRef Google Scholar

    [7] Tsang J. C. H., Vong J. S. L., Ji L., et al. (2017). Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics. Proc. Natl. Acad. Sci. U. S. A. 114:E7786−E7795. DOI:10.1073/pnas.1710470114

    View in Article CrossRef Google Scholar

    [8] Moufarrej M. N., Vorperian S. K., Wong R. J., et al. (2022). Early prediction of preeclampsia in pregnancy with cell-free RNA. Nature 602:689−694. DOI:10.1038/s41586-022-04410-z

    View in Article CrossRef Google Scholar

    [9] Gupta S. K., Luo L. and Yen L. (2018). RNA-mediated gene fusion in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 115:E12295−E12304. DOI:10.1073/pnas.1814704115

    View in Article CrossRef Google Scholar

    [10] Yang H., Guo F., Guo Q., et al. (2022). The clinical value of PlGF and the sFlt1/PlGF ratio in the management of hypertensive pregnancy disorders: A retrospective real-world study in China. Clin. Chim. Acta 528:90−97. DOI:10.1016/j.cca.2022.01.021

    View in Article CrossRef Google Scholar

    • Cited by

  • Cite this article:

    Zhang S., Yang M., Pan Y., et al. (2025). The RNA fusion landscape of human placentae and pre-eclampsia. The Innovation Medicine 3:100159. https://doi.org/10.59717/j.xinn-med.2025.100159
    Zhang S., Yang M., Pan Y., et al. (2025). The RNA fusion landscape of human placentae and pre-eclampsia. The Innovation Medicine 3:100159. https://doi.org/10.59717/j.xinn-med.2025.100159

Welcome!

To request copyright permission to republish or share portions of our works, please visit Copyright Clearance Center's (CCC) Marketplace website at marketplace.copyright.com.

PDF
Figures(1)    

Share

  • Share the QR code with wechat scanning code to friends and circle of friends.

Article Metrics

Article views(2046) PDF downloads(864)

Relative Articles

Cited by

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return

    {{newsColumn.name}}

    {{newsColumn.name}}

    Stay connected

    {{newsColumn.name}}

    Website copyright © Innovation Press. Published articles are licensed under CC BY with copyright retained by the authors.