Pig-to-human lung xenotransplantation: A pioneering step toward clinical reality
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[1] Uzoigwe C. E. and Ali O. (2022). Genetically modified porcine-to-human cardiac xenotransplantation. N. Engl. J. Med. 387:1337. DOI:10.1056/NEJMc2210401 [2] Montgomery R. A., Stern J. M., Lonze B. E., et al. (2022). Results of two cases of pig-to-human kidney xenotransplantation. N. Engl. J. Med. 386:1889−1898. DOI:10.1056/NEJMoa2120238 [3] He J., Shi J., Yang C., et al. (2025). Pig-to-human lung xenotransplantation into a brain-dead recipient. Nat. Med. 31:3388−3393. DOI:10.1038/s41591-025-03861-x [4] Mohiuddin M. M., Singh A. K., Corcoran P. C., et al. (2016). Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft. Nat. Commun. 7:11138. DOI:10.1038/ncomms11138 [5] Yamada K., Yazawa K., Shimizu A., et al. (2005). Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat. Med. 11:32−34. DOI:10.1038/nm1172 -
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Xu J., Yang F., Luo W., et al. (2025). Pig-to-human lung xenotransplantation: A pioneering step toward clinical reality. The Innovation Medicine 3:100174. https://doi.org/10.59717/j.xinn-med.2025.100174
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Xu J., Yang F., Luo W., et al. (2025). Pig-to-human lung xenotransplantation: A pioneering step toward clinical reality. The Innovation Medicine 3:100174. https://doi.org/10.59717/j.xinn-med.2025.100174
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Figure 1.
Historical milestones and key gene-editing strategies in lung xenotransplantation.
