Advanced Search
Article Contents
ABOUT THIS ARTICLE
The Innovation Medicine > 2026 Vol. 4 > No. 2 > 100207
Next Article Previous Article
LETTER   Open Access     Cite

Pioneering depression treatment with temporal interference stimulation: Intracranial and clinical evidence in humans

  • 1.

    Department of Psychiatry, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

  • 2.

    Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai 200135, China; Clinical Research Center for Mental Disorders, School of Medicine, Tongji University, Shanghai 200135, China

  • 3.

    School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK

  • 4.

    Department of Neurosurgery, Clinical Neuroscience Center Comprehensive Epilepsy Unit, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

  • 5.

    Clinical Neuroscience Center, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China

  • 6.

    Department of Neurology, Xuanwu Hospital, Clinical Center for Epilepsy, Capital Medical University, Beijing 100053, China

  • 7.

    The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China

  • 8.

    Xi'an NeuroDome Medical Technology Co., Ltd., Xi’an 710077, China

  • 9.

    Department of Brain Sciences, Imperial College London, London SW7 2AZ, UK

  • 10.

    UK Dementia Research Institute, Imperial College, London W12 0NN, UK

  • 11.

    Department of Neurology & Stroke, University of Tübingen, Tübingen, Germany; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen 72076, Germany

  • 12.

    RuiJin-Mihoyo Laboratory, RuiJin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

  • 13.

    Department of Radiology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

  • 14.

    These authors contributed equally

    • Show all affliationsShow less
More Information
The Innovation Medicine  4(2),  https://doi.org/10.59717/j.xinn-med.2026.100207  |  Cite this article
    • FullText(HTML)
  • 加载中
    • REFERENCES
  • [1] Grossman N., Bono D., Dedic N., et al. (2017). Noninvasive deep brain stimulation via temporally interfering electric fields. Cell 169:1029−1041.e16. DOI:10.1016/j.cell.2017.05.024

    View in Article CrossRef Google Scholar

    [2] Wessel M.J., Beanato E., Popa T., et al. (2023). Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning. Nat. Neurosci. 26:2005−2016. DOI:10.1038/s41593-023-01457-7

    View in Article CrossRef Google Scholar

    [3] Vassiliadis P., Beanato E., Popa T., et al. (2024). Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills. Nat. Hum. Behav. 8:1581−1598. DOI:10.1038/s41562-024-01901-z

    View in Article CrossRef Google Scholar

    [4] Violante I.R., Alania K., Cassarà A.M., et al. (2023). Non-invasive temporal interference electrical stimulation of the human hippocampus. Nat. Neurosci. 26:1994−2004. DOI:10.1038/s41593-023-01456-8

    View in Article CrossRef Google Scholar

    [5] Lamoš M., Bočková M., Missey F., et al. (2025). Noninvasive temporal interference stimulation of the subthalamic nucleus in Parkinson’s disease reduces beta activity. Mov. Disord. 40:1051−1060. DOI:10.1002/mds.30134

    View in Article CrossRef Google Scholar

    [6] Yang C., Xu Y., Feng X., et al. (2025). Transcranial temporal interference stimulation of the right globus pallidus in Parkinson’s disease. Mov. Disord. 40:1061−1069. DOI:10.1002/mds.29967

    View in Article CrossRef Google Scholar

    [7] Fitzgerald P.B. (2021). Targeting repetitive transcranial magnetic stimulation in depression: Do we really know what we are stimulating and how best to do it. Brain Stimul. 14:730−736. DOI:10.1016/j.brs.2021.04.018

    View in Article CrossRef Google Scholar

    [8] Li B., Friston K., Mody M., et al. (2018). A brain network model for depression: From symptom understanding to disease intervention. CNS Neurosci. Ther. 24:1004−1019. DOI:10.1111/cns.12998

    View in Article CrossRef Google Scholar

    [9] Johnson K.A., Okun M.S., Scangos K. et al. (2024). Deep brain stimulation for refractory major depressive disorder: A comprehensive review. Mol. Psychiatry 29:1075−1087. DOI:10.1038/s41380-023-02394-4

    View in Article CrossRef Google Scholar

    [10] Langevin J.-P. (2012). The amygdala as a target for behavior surgery. Surg. Neurol. Int. 3:S40−46. DOI:10.4103/2152-7806.91609

    View in Article CrossRef Google Scholar

    • Cited by

  • Cite this article:

    Yan J., Zhou S., Chen Y., et al. (2026). Pioneering depression treatment with temporal interference stimulation: Intracranial and clinical evidence in humans. The Innovation Medicine 4:100207. https://doi.org/10.59717/j.xinn-med.2026.100207
    Yan J., Zhou S., Chen Y., et al. (2026). Pioneering depression treatment with temporal interference stimulation: Intracranial and clinical evidence in humans. The Innovation Medicine 4:100207. https://doi.org/10.59717/j.xinn-med.2026.100207

Welcome!

To request copyright permission to republish or share portions of our works, please visit Copyright Clearance Center's (CCC) Marketplace website at marketplace.copyright.com.

PDF
Figures(1)    

Share

  • Share the QR code with wechat scanning code to friends and circle of friends.

Article Metrics

Article views(2554) PDF downloads(939)

Relative Articles

Cited by

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return

    {{newsColumn.name}}

    {{newsColumn.name}}

    Stay connected

    {{newsColumn.name}}

    Website copyright © Innovation Press. Published articles are licensed under CC BY with copyright retained by the authors.