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The Innovation Nutrition > 2026 Vol. 1 > No. 2 > 100021
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Deconstructing the breast milk "black box": Trans-vaccenic acid as a precision immune signal in neonatal development

  • 1.

    Institute of Haematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

  • 2.

    Key Laboratory of Biological Targeted Therapy (Huazhong University of Science and Technology), Ministry of Education, Wuhan 430022, China

  • 3.

    Diagnostic Science Centre, Alberta Precision Laboratories, Calgary, AB T1Y 5S3, Canada

  • 4.

    These authors contributed equally

More Information
  • Corresponding authors: dr_huyu@126.com (Y.H.); lancet.tang@qq.com (L.T.)
  • Received Date:  June 26, 2026
    Accepted Date:  July 04, 2026
    Published Online:  July 16, 2026
The Innovation Nutrition  1(2),  https://doi.org/10.59717/j.xinn-nutri.2026.100021  |  Cite this article
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    • REFERENCES
  • [1] Andres S., Scottoline B. and Good M. (2023) Shaping infant development from the inside out: Bioactive factors in human milk. Semin. Perinatol. 47:151690. DOI: 10.1016/j.semperi.2022.151690

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    [2] Fan H., Zheng Z., Oliphant K., et al. (2026). Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting. Science 392:eaea4041. DOI: 10.1126/science.aea4041

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    [3] Fan H., Xia S., Xiang J., et al. (2023). Trans-vaccenic acid reprograms CD8(+) T cells and anti-tumour immunity. Nature 623:1034-1043. DOI: 10.1038/s41586-023-06749-3

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    [4] Ju C., Lyu R., Li H., et al. (2026). Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples. Nat. Biotechnol. 44:752−8. DOI:10.1038/s41587-025-02731-8

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  • Cite this article:

    Li Q., Li X., Tang L., et al. (2026). Deconstructing the breast milk 'black box': Trans-vaccenic acid as a precision immune signal in neonatal development. The Innovation Nutrition 1:100021. https://doi.org/10.59717/j.xinn-nutri.2026.100021
    Li Q., Li X., Tang L., et al. (2026). Deconstructing the breast milk "black box": Trans-vaccenic acid as a precision immune signal in neonatal development. The Innovation Nutrition 1:100021. https://doi.org/10.59717/j.xinn-nutri.2026.100021

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