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The Innovation Oncology > 2026 Vol. 1 > No. 2 > 100021
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Practical guideline for the diagnosis and management of central nervous system germ cell tumors

  • 1.

    Department of Emergency, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China

  • 2.

    Clinical medicine, School of Medicine, Jianghan University, Wuhan 430000, China

  • 3.

    Department of Pediatric Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China

  • 4.

    Department of Pediatric Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

  • 5.

    Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China

  • 6.

    These authors contributed equally to this work

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The Innovation Oncology  1(2),  https://doi.org/10.59717/j.xinn-oncol.2026.100021  |  Cite this article
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    • REFERENCES
  • [1] Bartels U., Onar-Thomas A., Patel S.K., et al. (2022). Phase II trial of response-based radiation therapy for patients with localized germinoma: A Children's Oncology Group study. Neuro. Oncol. 24:974−983. DOI:10.1093/neuonc/noab270

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    [2] Frappaz D., Dhall G., Murray M.J., et al. (2022). EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults. Neuro. Oncol. 24:516−527. DOI:10.1093/neuonc/noab252

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    [3] Calaminus G., Frappaz D., Kortmann R.D., et al. (2017). Outcome of patients with intracranial non-germinomatous germ cell tumors-lessons from the SIOP-CNS-GCT-96 trial. Neuro. Oncol. 19:1661−1672. DOI:10.1093/neuonc/nox122

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    [4] Fangusaro J., Wu S., MacDonald S., et al. (2019). Phase II trial of response-based radiation therapy for patients with localized CNS nongerminomatous germ cell tumors: A Children's Oncology Group study. J. Clin. Oncol. 37:3283−3290. DOI:10.1200/JCO.19.00701

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    [5] Chao Z., Xiang H., Yijin G., et al. (2025). CACA guidelines for holistic integrative management of central nervous system germ cell tumor. Holist. Integ. Oncol. 40:1−21. DOI:10.1007/s44178-025-00168-2

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  • Cite this article:

    Chen Z., Cheng B.-x., Tang C.-p., et al. (2026). Practical guideline for the diagnosis and management of central nervous system germ cell tumors. The Innovation Oncology 1:100021. https://doi.org/10.59717/j.xinn-oncol.2026.100021
    Chen Z., Cheng B.-x., Tang C.-p., et al. (2026). Practical guideline for the diagnosis and management of central nervous system germ cell tumors. The Innovation Oncology 1:100021. https://doi.org/10.59717/j.xinn-oncol.2026.100021

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