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TPPP/p25 amyloid seeding in multiple system atrophy: From structural self-protection toward a disease-specific biomarker

  • 1.

    Department of Pharmacy, Shanghai Sixth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China

  • 2.

    College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China

  • 3.

    College of Clinical Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

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  • Corresponding author: myotime@sjtu.edu.cn
  • Received Date:  July 09, 2026
    Accepted Date:  September 23, 2026
    Published Online:  September 24, 2026
The Innovation Insights  https://doi.org/10.59717/j.tiis.2026.100012  |  Cite this article
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    • REFERENCES
  • [1] Wiseman J. A., Turner C. P., Faull R. L. M., et al. (2025). Refining α-synuclein seed amplification assays to distinguish Parkinson's disease from multiple system atrophy. Transl. Neurodegener 14:7. DOI:10.1186/s40035-025-00469-6

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    [2] Zeng S., Zhang S., Zhang S., et al. (2026). TPPP/p25 amyloid seeding activity as a specific biomarker for multiple system atrophy. Cell 189:4724-4736. DOI:10.1016/j.cell.2026.04.050

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    [3] Ferreira N., Gram H., Sorrentino Z. A., et al. (2021). Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential. Acta Neuropathol. 142:87−115. DOI:10.1007/s00401-021-02316-0

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    [4] Ma Y., Farris C. M., Weber S., et al. (2024). Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study. Lancet Neurol. 23:1225−1237. DOI:10.1016/s1474-4422(24)00395-8

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    [5] Katzdobler S., Nübling G., Klietz M., et al. (2024). GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA). J Neurol. 271:6991−6999. DOI:10.1007/s00415-024-12647-z

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  • Cite this article:

    Jin S. and Yang Q. (2026). TPPP/p25 amyloid seeding in multiple system atrophy: From structural self-protection toward a disease-specific biomarker. The Innovation Insights 1:100012. https://doi.org/10.59717/j.tiis.2026.100012
    Jin S. and Yang Q. (2026). TPPP/p25 amyloid seeding in multiple system atrophy: From structural self-protection toward a disease-specific biomarker. The Innovation Insights 1:100012. https://doi.org/10.59717/j.tiis.2026.100012

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