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Retention elements sustain persistent inheritance of extrachromosomal DNA in cancer cells

  • 1.

    Jiangsu Key Laboratory of Innovative Cancer Diagnosis & Therapeutics, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210000, China

  • 2.

    Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China

  • 3.

    Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China

  • 4.

    Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

  • 5.

    Department of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China

  • 6.

    These authors contributed equally

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The Innovation Medicine  https://doi.org/10.59717/j.xinn-med.2027.100281  |  Cite this article
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    • REFERENCES
  • [1] Yan X., Mischel P. and Chang H. (2024). Extrachromosomal DNA in cancer. Nat. Rev. Cancer 24:261−273. DOI:10.1038/s41568-024-00669-8

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    [2] Nichols A., Choi Y., Norman R.X., et al. (2025). Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance. Mol. Cell 85:2839−2853.e8. DOI:10.1016/j.molcel.2025.06.013

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    [3] Sankar V., Hung K.L., Gnanasekar A., et al. (2025). Genetic elements promote retention of extrachromosomal DNA in cancer cells. Nature 649:152−160. DOI:10.1038/s41586-025-09764-8

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    [4] Pattali R.K., Ornelas I.J., Nguyen C.D., et al. (2025). CRISPRoff epigenome editing for programmable gene silencing in human cell lines and primary T cells. Methods Enzymol. 712:517−551. DOI:10.1016/bs.mie.2025.01.010

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    Chen S., Shao Y., Liu B., et al. (2027). Retention elements sustain persistent inheritance of extrachromosomal DNA in cancer cells. The Innovation Medicine 5:100281. https://doi.org/10.59717/j.xinn-med.2027.100281
    Chen S., Shao Y., Liu B., et al. (2027). Retention elements sustain persistent inheritance of extrachromosomal DNA in cancer cells. The Innovation Medicine 5:100281. https://doi.org/10.59717/j.xinn-med.2027.100281

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