Arc at the virus–synapse interface: A domesticated capsid that writes memory and disseminates neurodegeneration
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[1] Tyagi M., de Hoog E., Grega M., et al. (2026). Arc mediates intercellular tau transmission via extracellular vesicles. Cell 189:4706−4723.e4713. DOI:10.1016/j.cell.2026.06.008 [2] Pastuzyn E. D., Day C. E., Kearns R. B., et al. (2018). The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. Cell 172:275−288.e218. DOI:10.1016/j.cell.2017.12.024 [3] Ashley J., Cordy B., Lucia D., et al. (2018). Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons. Cell 172:262−274.e211. DOI:10.1016/j.cell.2017.12.022 [4] Fowler S. L., Behr T. S., Turkes E., et al. (2025). Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease. Nat. Neurosci. 28:40−48. DOI:10.1038/s41593-024-01801-5 [5] Wu J. W., Hussaini S. A., Bastille I. M., et al. (2016). Neuronal activity enhances tau propagation and tau pathology in vivo. Nat. Neurosci. 19:1085−1092. DOI:10.1038/nn.4328 -
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Lu Y., Zhang Y. and Zhang H. (2026). Arc at the virus–synapse interface: A domesticated capsid that writes memory and disseminates neurodegeneration. The Innovation Neurology 1:100004. https://doi.org/10.59717/j.xinn-tine.2026.100004
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Lu Y., Zhang Y. and Zhang H. (2026). Arc at the virus–synapse interface: A domesticated capsid that writes memory and disseminates neurodegeneration. The Innovation Neurology 1:100004. https://doi.org/10.59717/j.xinn-tine.2026.100004
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Figure 1.
Local and network effects of Arc-dependent tau dissemination
