A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients

Zhe Zhang; Wenjing Yang; Zhengshan Chen; Haoang Chi; Shipo Wu; Wanru Zheng; Ruochun Jin; Busen Wang; Yudong Wang; Nan Huo; Jinlong Zhang; Xiaohong Song; Liyang Xu; Jun Zhang; Lihua Hou; Wei Chen

doi:10.1016/j.xinn.2024.100603

The Innovation > 2024 Vol. 5 > No. 3

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A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients

1.
Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
2.
Department of Intelligent Data Science, College of Computer Science and Technology, National University of Defense Technology, Changsha 410073, China
3.
Intelligent Game and Decision Lab, Academy of Military Science, Beijing 100091, China

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⁴ These authors contributed equally
Corresponding authors: houlihua@sina.com (L.H.); cw0226@foxmail.com (W.C.)
Received Date: July 07, 2023

Accepted Date: February 28, 2024

Published Online: March 02, 2024

The Innovation 5(3), https://doi.org/10.1016/j.xinn.2024.100603 | Cite this article

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1. ■ The increase in GP_1,2-specific IgG induced by Ad5-EBOV was strongly correlated with the development of early antiviral and inflammatory responses.
2. ■ Greater innate immune responses were elicited in Ad5-EBOV recipients with lower preexisting Ad5 immunity.
3. ■ A general causality-based tool was proposed to analyze multiomics vaccine immune responses.

ABSTRACT

ABSTRACT

The vaccine-induced innate immune response is essential for the generation of an antibody response. To date, how Ad5-vectored vaccines are influenced by preexisting anti-Ad5 antibodies during activation of the early immune response remains unclear. Here, we investigated the specific alterations in GP_1,2-specific IgG-related elements of the early immune response at the genetic, molecular, and cellular levels on days 0, 1, 3, and 7 after Ad5-EBOV vaccination. In a causal multiomics analysis, distinct early immune responses associated with GP_1,2-specific IgG were observed in Ad5-EBOV recipients with a low level of preexisting anti-Ad5 antibodies. This study revealed the correlates of the Ad5-EBOV-induced IgG response and provided mechanistic evidence for overcoming preexisting Ad5 immunity during the administration of Ad5-vectored vaccines.

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Zhang Z., Yang W., Chen Z., et al., (2024). A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients. The Innovation 5(3), 100603. https://doi.org/10.1016/j.xinn.2024.100603

Zhang Z., Yang W., Chen Z., et al., (2024). A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients. The Innovation 5(3), 100603. https://doi.org/10.1016/j.xinn.2024.100603

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A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients

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