Hyocholic acid: A novel therapeutic strategy for metabolic syndrome

Bohan Rong; Qian Zhang; Xiaohan Zhang; Na Zhang; Zhentong Shen; Yu Pang; Xu Lin; Di Liu; Xiuqin Yang

doi:10.59717/j.xinn-life.2024.100093

The Innovation Life > 2024 Vol. 2 > No. 4 > 100093

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Hyocholic acid: A novel therapeutic strategy for metabolic syndrome

1.
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China
2.
Institute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China
3.
College of life Science, Nankai University, Tianjin 300071, China
4.
Engineering Research Center for Intelligent Breeding and Farming of Pig in Northern Cold Region, Ministry of Education, Harbin 150030, China
5.
These authors contributed equally

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Corresponding authors: rbh19901116@163.com (B.R.); liudi1963@163.com (D.L.); xiuqinyang@neau.edu.cn (X.Y.)
Received Date: January 29, 2024

Accepted Date: September 04, 2024

Published Online: October 09, 2024

The Innovation Life 2(4), https://doi.org/10.59717/j.xinn-life.2024.100093 | Cite this article

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GRAPHICAL ABSTRACT

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PUBLIC SUMMARY

PUBLIC SUMMARY
1. Hyocholic acid is critical for the anti-energy dysmetabolism capacity in domestic pigs.
  
  Hyocholic acid is a strong predictor and potential therapy for clinical glucolipid dysmetabolism.
  
  Bacteriogenic biotransformation affirms the polyphyly of hyocholic acid in mammals.
  
  Non-hepatic tissues are new research targets for the pharmaceutical development of hyocholic acid.

ABSTRACT

ABSTRACT

The outdated definition of bile acids (BAs) as a sort of metabolic adjuvant for lipid and lipidic solubility should be expired. Mammalian BAs are widespread, tautomeric, polyphyletic, and biosynthetic metabolites that extensively serve as bio-messengers and can be used to characterize various physiological states. Among these, hyocholic acid species (HCAs) have received considerable interest due to their strong potential to alleviate energy dysmetabolism, especially glucolipid metabolic disorder. Effective integration of gut microbiomics, glycolipidomics, and other omics contributes to establishing the regulation process of BA signaling on glucolipid metabolism. In a three-dimensional system, HCAs (1) remodel the structure of the gut microbiome, the pattern of reabsorbed secondary BAs, and intestinal lipid uptake efficiency by increasing the hydrophilicity of the total BA pool and reducing cytotoxicity; (2) dynamically shape the profile of hepatic lipometabolism and primary BA biosynthesis via enterohepatic circulation and feedback regulation-based network between gut microbiota and host, and (3) serve as a serious of output signals which are responsible for tuning energy physiology of peripheral tissue. These multidimensional influences allow HCAs to improve the gut microbiome, inhibit excessive lipid uptake, and remodel glucolipid metabolic flux distribution that enhances resistance to metabolic syndrome. Increasing attention to HCAs in clinical and animal studies emphasizes the vital potential of BAs in tracing the role of environmental factors in the evolutionary process of associated species and opens a novel perspective to develop BAs into clinically therapeutic strategies and variety breeding.

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Rong B., Zhang Q., Zhang X., et al., (2024). Hyocholic acid: A novel therapeutic strategy for metabolic syndrome. The Innovation Life 2(4): 100093. https://doi.org/10.59717/j.xinn-life.2024.100093

Rong B., Zhang Q., Zhang X., et al., (2024). Hyocholic acid: A novel therapeutic strategy for metabolic syndrome. The Innovation Life 2(4): 100093. https://doi.org/10.59717/j.xinn-life.2024.100093

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