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The Innovation Medicine > 2026 Vol. 4 > No. 3 > 100226
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Breaking the classic niche model: HSC quantity dually constrained by systemic and local factors

  • 1.

    Department of Biochemistry and Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing 100080, China

  • 2.

    The Institute of Blood Transfusion, Chinese Academy of Medical Sciences, and Peking Union Medical College, Chengdu 610052, China

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  • Corresponding author: j-yu@ibms.pumc.edu.cn
  • Received Date:  December 01, 2025
    Accepted Date:  May 30, 2026
    Published Online:  May 31, 2026
The Innovation Medicine  4(3),  https://doi.org/10.59717/j.xinn-med.2026.100226  |  Cite this article
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    • REFERENCES
  • [1] Schofield R. (1978). The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4:7−25.

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    [4] Du C., Liu C., Yu K., et al. (2024). Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury. Cell Stem Cell 31:1484−1500.e9. DOI:10.1016/j.stem.2024.07.009

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    [5] Takeishi S., Marchand T., Koba W.R., et al. (2025). Haematopoietic stem cell number is not solely defined by niche availability. Nature 646:687−696. DOI:10.1038/s41586-025-09462-5

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  • Cite this article:

    Li W., Wang F. and Yu J. (2026). Breaking the classic niche model: HSC quantity dually constrained by systemic and local factors. The Innovation Medicine 4:100226. https://doi.org/10.59717/j.xinn-med.2026.100226
    Li W., Wang F. and Yu J. (2026). Breaking the classic niche model: HSC quantity dually constrained by systemic and local factors. The Innovation Medicine 4:100226. https://doi.org/10.59717/j.xinn-med.2026.100226

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