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The Innovation Medicine > 2026 Vol. 4 > No. 3 > 100228
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Active presynaptic regulation, besides passive depletion, underlies DBS efficacy

  • 1.

    Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China

  • 2.

    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

  • 3.

    Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

  • 4.

    Department of Psychological and Cognitive Sciences, Tsinghua University, Beijing 100084, China

  • 5.

    Chinese Institute for Brain Research, Beijing 102206, China

  • 6.

    These authors contributed equally

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The Innovation Medicine  4(3),  https://doi.org/10.59717/j.xinn-med.2026.100228  |  Cite this article
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  • [1] Li J., Zhou J., He B., et al. (2025). Differential synaptic depression mediates the therapeutic effect of deep brain stimulation. Nat. Neurosci. 28:2575−2587. DOI:10.1038/s41593-025-02088-w

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    [2] Du D., Fu W., Su S., et al. (2025). Remote regulation of molecular diffusion in extracellular space of Parkinson's disease rat model by subthalamic nucleus deep brain stimulation. Cyborg Bionic Syst. 6:0218. DOI:10.34133/cbsystems.0218

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    [3] Alten B., Guzikowski N.J., Zurawski Z., et al. (2022). Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release. Cell Rep. 38:110255. DOI:10.1016/j.celrep.2021.110255

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    [4] Xu Z., Duan W., Yuan S., et al. (2025). Deep brain stimulation alleviates Parkinsonian motor deficits through desynchronizing GABA release in mice. Nat. Commun. 16:3726. DOI:10.1038/s41467-025-59113-6

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    [5] Gao J., Gao Y., Wang H., et al. (2024). Late-stage Parkinson’s disease: Skilled walking with a neuroprosthesis. Innov. Med. 2:100073. DOI:10.59717/j.xinn-med.2024.100073

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  • Cite this article:

    Li J., Wang H., Gao Y., et al. (2026). Active presynaptic regulation, besides passive depletion, underlies DBS efficacy. The Innovation Medicine 4:100228. https://doi.org/10.59717/j.xinn-med.2026.100228
    Li J., Wang H., Gao Y., et al. (2026). Active presynaptic regulation, besides passive depletion, underlies DBS efficacy. The Innovation Medicine 4:100228. https://doi.org/10.59717/j.xinn-med.2026.100228

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