Magnetic nanoparticle-mediated hyperthermia: From heating mechanisms to cancer theranostics
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PUBLIC SUMMARY
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Heating mechanisms of magnetic nanoparticles under an alternating magnetic field are introduced.
Approaches to boost the specific absorption rate of magnetic nanoparticles are summarized.
Biological effects of magnetic hyperthermia on hierarchical structures in vivo are discussed.
Synergistic treatment and diagnosis via magnetic hyperthermia in biomedical applications are presented.
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ABSTRACT
Magnetic nanoparticle-mediated hyperthermia (MHT) is a promising tumor theranostic technology due to its noninvasive nature and ability to penetrate deep tissues without greatly damaging normal tissues. To advance the clinical translation and application of MHT, we present a comprehensive overview of topics related to MHT, including the basic physical heating principles, magnetic nanoparticle design, biological effects and theranostic applications. First, the fundamental physical principles through which magnetic nanoparticles mediate hyperthermia are reviewed in detail. Subsequently, strategies to increase the magnetothermal effect and biological effects of MHT are highlighted. Then, MHT and multitechnology integration applications in precision diagnosis and treatment are introduced. Finally, the key challenges and outlooks of MHT for clinical purposes are discussed. -
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REFERENCES
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Bai S., Hou S., Chen T., et al., (2024). Magnetic nanoparticle-mediated hyperthermia: From heating mechanisms to cancer theranostics. The Innovation Materials 2(1): 100051. https://doi.org/10.59717/j.xinn-mater.2024.100051
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Bai S., Hou S., Chen T., et al., (2024). Magnetic nanoparticle-mediated hyperthermia: From heating mechanisms to cancer theranostics. The Innovation Materials 2(1): 100051. https://doi.org/10.59717/j.xinn-mater.2024.100051
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Figure 1.
Schematic of the magnetic dipole arrangements of five different magnetic materials in the absence and presence of an external magnetic field (H).
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Figure 2.
Schematic illustrations of the physical properties of magnetic materials
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Figure 3.
Parameters of MNPs for optimizing SAR
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Figure 4.
Multifunctional surface modification
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Figure 5.
Self-assembled magnetic nanoparticles
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Figure 6.
Smart assembly of magnetic composites
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Figure 7.
Biological effects of magnetic material-mediated magnetic hyperthermia
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Figure 8.
Synergistic theranostics based on MHT
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Figure 9.
Imaging-guided MHT
