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The Innovation Medicine > 2025 Vol. 3 > No. 1 > 100110
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Two birds with one stone — Semaglutide's impacts on obesity and knee osteoarthritis: From weight loss to pain relief

  • 1.

    Department of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Hong Kong SAR 999077, China

  • 2.

    Center for Neuromusculoskeletal Restorative Medicine, Hong Kong Science and Technology Park, Hong Kong SAR 999077, China

  • 3.

    Department of Biomedical Engineering, School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, China

  • 4.

    Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China

  • 5.

    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China

  • 6.

    Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China

  • 7.

    Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania 7000, Australia

  • 8.

    Peter Hung Pain Research Institute, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China

  • 9.

    These authors contributed equally

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The Innovation Medicine  3(1),  https://doi.org/10.59717/j.xinn-med.2025.100110  |  Cite this article
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    • REFERENCES
  • [1] Steinmetz J. D., Culbreth G. T., Haile L. M., et al. (2023). Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: A systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol. 5:e508−e522. DOI:10.1016/S2665-9913(23)00163-7

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    [2] Anekwe C. V., Jarrell A. R., Townsend M. J., et al. (2020). Socioeconomics of obesity. Curr. Obes. Rep. 9:272−279. DOI:10.1007/s13679-020-00398-7

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    [3] Chen L., Zheng J. J. Y., Li G., et al. (2020). Pathogenesis and clinical management of obesity-related knee osteoarthritis: Impact of mechanical loading. J. Orthop. Translat. 24:66−75. DOI:10.1016/j.jot.2020.05.001

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    [4] Bliddal H., Bays H., Czernichow S., et al. (2024). Once-weekly Semaglutide in persons with obesity and knee osteoarthritis. N. Engl. J. Med. 391:1573−1583. DOI:10.1056/NEJMoa2403664

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    [5] Zhu H., Zhou L., Wang Q., et al. (2023). Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: Findings from the Shanghai Osteoarthritis Cohort. Ann. Rheum. Dis. 82:1218−1226. DOI:10.1136/ard-2023-223845

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  • Cite this article:

    Zhou L., He S., Li C., et al. (2025). Two birds with one stone — Semaglutide's impacts on obesity and knee osteoarthritis: From weight loss to pain relief. The Innovation Medicine 3:100110. https://doi.org/10.59717/j.xinn-med.2025.100110
    Zhou L., He S., Li C., et al. (2025). Two birds with one stone — Semaglutide's impacts on obesity and knee osteoarthritis: From weight loss to pain relief. The Innovation Medicine 3:100110. https://doi.org/10.59717/j.xinn-med.2025.100110

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