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The Innovation Medicine > 2026 Vol. 4 > No. 3 > 100221
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High-dose influenza vaccination in older adults: Reconciling trial evidence for policy

  • 1.

    Institute of the Immunology Program, Wuhan Center for Disease Control and Prevention, Wuhan 430000, China

  • 2.

    Institute of Infections Diseases Control and Prevention, Hubei center for diseases Control and Prevention, Wuhan 430079,China

  • 3.

    Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China

  • 4.

    These authors contributed equally

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  • Corresponding author: t_yeqing@163.com
  • Received Date:  January 07, 2026
    Accepted Date:  May 15, 2026
    Published Online:  May 16, 2026
The Innovation Medicine  4(3),  https://doi.org/10.59717/j.xinn-med.2026.100221  |  Cite this article
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    • REFERENCES
  • [1] Monto A.S., Ansaldi F., Aspinall R., et al. (2009). Influenza control in the 21st century: Optimizing protection of older adults. Vaccine 27:5043−53. DOI:10.1016/j.vaccine.2009.06.032

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    [2] Goodwin K., Viboud C. and Simonsen L. (2006). Antibody response to influenza vaccination in the elderly: A quantitative review. Vaccine 24:1159−1169. DOI:10.1016/j.vaccine.2005.08.105

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    [3] Falsey A.R., Treanor J.J., Tornieporth N., et al. (2009). Randomized, double-blind controlled phase III trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older. J. Infect. Dis. 200:172−180. DOI:10.1086/599790

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    [4] Pardo-Seco J., Rodríguez-Tenreiro-Sánchez C., González-Melón L., et al. (2025). High-dose influenza vaccine to reduce hospitalizations. N. Engl. J. Med. 393:2303−2312. DOI:10.1056/NEJMoa2501234

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    [5] Johansen N.D., Modin D., Kjøller-Hansen L., et al. (2025). High-dose influenza vaccine effectiveness against hospitalization in older adults. N. Engl. J. Med. 393:2291−2302. DOI:10.1056/NEJMoa2501229

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  • Cite this article:

    Cai L., Hu X., Lin L., et al. (2026). High-dose influenza vaccination in older adults: Reconciling trial evidence for policy. The Innovation Medicine 4:100221. https://doi.org/10.59717/j.xinn-med.2026.100221
    Cai L., Hu X., Lin L., et al. (2026). High-dose influenza vaccination in older adults: Reconciling trial evidence for policy. The Innovation Medicine 4:100221. https://doi.org/10.59717/j.xinn-med.2026.100221

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