Emerging contaminants and their impacts on atopic dermatitis: Current mechanisms and future perspectives
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PUBLIC SUMMARY
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Definitions of emerging contaminants (ECs) are changing with the times.
ECs exhibit varied effects on atopic dermatitis, showing both exacerbating and protective potential.
Recommendations for the optimization of living environments and lifestyles are presented from the EC perspective.
Future research should focus on identifying high-priority ECs and their synergistic effects on AD.
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ABSTRACT
With the progression of industrialization and urbanization, the diversity and concentration of emerging contaminants (ECs) in the environment have risen concomitantly. Atopic dermatitis (AD) is a chronic inflammatory skin condition driven by genetic and environmental factors. Research on the interactions between ECs and AD has expanded significantly in recent decades. This review examines the complex interplay between representative environmental ECs and AD, focusing on mechanisms of immune disruption, including Th2 polarization and aryl hydrocarbon receptor (AhR) activation. Drawing on recent evidence, we further identify critical research gaps to guide future investigations into the impacts of ECs on AD, highlight clinical implications and propose potential strategies for exposure reduction and lifestyle adjustments to prevent and manage AD. -
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REFERENCES
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Huang L., Zhou Y., Xiao H., et al. (2026). Emerging contaminants and their impacts on atopic dermatitis: Current mechanisms and future perspectives. The Innovation Medicine 4:100233. https://doi.org/10.59717/j.xinn-med.2026.100233
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Huang L., Zhou Y., Xiao H., et al. (2026). Emerging contaminants and their impacts on atopic dermatitis: Current mechanisms and future perspectives. The Innovation Medicine 4:100233. https://doi.org/10.59717/j.xinn-med.2026.100233
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Content
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Figure 1.
Pathways through ECs and the environment
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Figure 2.
The common ECs and exposure ways
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Figure 3.
Aryl Hydrocarbon Receptor (AhR) activation by ECs
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Figure 4.
Major pathways by which ECs affect AD
