Cold exposure and acute chest pain-related life-threatening cardiovascular diseases: A scientific statement

Meilin Yan; Qinghua Sun; Jing Yang; Xingqin An; Jie Ban; Wenjia Cai; Qingchen Chao; Hui Chen; Lianglong Chen; Renjie Chen; Siyu Chen; Yundai Chen; Yuxiang Dai; Peng Du; Weiyi Fang; Chuanyu Gao; Xiaoyu Guan; Jian Hang; Cunrui Huang; Dong Huang; Kai Huang; Yong Huo; John S. Ji; Haidong Kan; Hong Liao; Fangchao Liu; Feng Liu; Bo Lu; Peng Lv; Bin Luo; Genshan Ma; Wenjun Ma; Wei Ma; Bin Wang; Qing Wang; Shigong Wang; Dingcheng Xiang; Yawei Xu; Can Zhang; Taiyuan Zhang; Xiaofeng Xu; Junbo Ge; Tiantian Li

doi:10.59717/j.xinn-med.2026.100232

The Innovation Medicine > 2026 Vol. 4 > No. 3 > 100232

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Cold exposure and acute chest pain-related life-threatening cardiovascular diseases: A scientific statement

1.
Department of Environmental Science and Engineering, Beijing Technology and Business University, Beijing 102488, China
2.
China Meteorological Administration Key Laboratory of Meteorological Medicine and Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China
3.
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China
4.
CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China
5.
National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China
6.
Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Shanghai 200031, China
7.
China Academy of Meteorological Sciences, Beijing 100081, China
8.
Department of Earth System Science, Institute for Global Change Studies, Ministry of Education Ecological Field Station for East Asian Migratory Birds, Tsinghua University, Beijing 100084, China
9.
National Climate Center, China Meteorological Administration, Beijing 100081, China
10.
China Meteorological Administration Key Laboratory of Meteorological Medicine and Health, National Climate Centre, Beijing 100081, China
11.
Public Meteorological Service Centre, China Meteorological Administration, Beijing 100081, China
12.
Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou 350001, China
13.
Fujian Cardiovascular Medicine Center, Fuzhou 350001, China
14.
Fujian Institute of Coronary Artery Disease, Fuzhou 350001, China
15.
School of Public Health, Fudan University, Shanghai 200032, China
16.
Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, Lanzhou University, Lanzhou 730000, China
17.
Senior Department of Cardiology, the Sixth Medical Center of PLA General Hospital, Beijing 100053, China
18.
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China
19.
State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China
20.
NHC Key Laboratory of Ischemic Heart Diseases, Shanghai 200032, China
21.
Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai 200032, China
22.
National Clinical Research Center for Interventional Medicine, Shanghai 200032, China
23.
Shanghai Chest Hospital, Shanghai 200030, China
24.
Fuwai Central China Cardiovascular Hospital, Zhengzhou 450000, China
25.
China Heart House, Suzhou 215000, China
26.
School of Atmospheric Sciences, Sun Yat-sen University, Zhuhai 519082, China
27.
Vanke School of Public Health, Tsinghua University, Beijing 100084, China
28.
Renmin Hospital of Wuhan University, Wuhan 430060, China
29.
Peking University First Hospital, Beijing 100034, China
30.
State Key Laboratory of Climate System Prediction and Risk Management, University of Information Science & Technology, Nanjing 211544, China
31.
Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
32.
Department of Cardiology, Suzhou Kowloon Hospital Shanghai Jiao Tong University School of Medicine, Suzhou 215127, China
33.
State Key Laboratory of Climate System Prediction and Risk Management/China Meteorological Administration Climate Studies Key Laboratory, National Climate Centre, China Meteorological Administration, Beijing 100081, China
34.
Hebei Key Laboratory of Meteorological Artificial Intelligence, Xiong’an Institute of Meteorological Artificial Intelligence, Xiongan New Area 071700, China
35.
Binzhou Medical University, Yantai 264003, China
36.
School of Public Health, Lanzhou University, Lanzhou 730000, China
37.
Zhongda Hospital Southeast University, Nanjing 210009, China
38.
School of Medicine, Jinan University, Guangzhou 510632, China
39.
School of Public Health, Shandong University, Jinan 250012, China
40.
Shandong University Climate Change and Health Center, Jinan 250012, China
41.
Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China
42.
Fujian Branch of National Clinical Research Center for Cardiovascular Diseases, Xiamen 361102, China
43.
College of Atmospheric Sciences/Institute of Environmental Meteorology and Health, Chengdu University of Information Technology, Chengdu 610103, China
44.
Department of Cardiology, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, China
45.
Shanghai Public Health Clinical Center, Shanghai 201508, China
46.
Huafeng Meteorological Media Group, China Meteorological Administration, Beijing 100081, China
47.
China Meteorological Administration Key Laboratory of Meteorological Medicine and Health, Huafeng Meteorological Media Group, China Meteorological Administration, Beijing 100081, China
48.
China Meteorological Service Association, Beijing 100081, China
49.
China Meteorological Administration Key Laboratory of Meteorological Medicine and Health, China Meteorological Service Association, Beijing 100081, China
50.
These authors contributed equally

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Corresponding authors: litiantian@nieh.chinacdc.cn (T.L.); xuxf@cma.gov.cn (X.X.); ge.junbo@zs-hospital.sh.cn (J.G.)
Received Date: January 19, 2026

Accepted Date: June 30, 2026

Published Online: July 01, 2026

The Innovation Medicine 4(3), https://doi.org/10.59717/j.xinn-med.2026.100232 | Cite this article

GRAPHICAL ABSTRACT

GRAPHICAL ABSTRACT

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PUBLIC SUMMARY

PUBLIC SUMMARY
1. Cold exposure is a major but preventable trigger of acute life-threatening cardiovascular events.
  
  Multidisciplinary evidence links cold exposure to coronary events, aortic dissection, and pulmonary embolism.
  
  Older adults, chronically ill patients, and low-SES communities are especially vulnerable to cold exposure.
  
  Integrated clinical, policy, and behavioral measures can reduce cold-related cardiovascular risks.

ABSTRACT

ABSTRACT

Climate change has amplified the variability and intensity of cold weather, contributing to a growing health burden. Cold exposure serves as a significant, yet preventable, environmental trigger for acute chest pain–related life-threatening cardiovascular diseases (CVDs), such as acute coronary syndrome, acute aortic dissection, and pulmonary embolism. This scientific statement synthesizes multidisciplinary evidence from meteorology, environmental epidemiology, basic science, and clinical research to offer an updated evaluation of the impact of cold exposure on these acute chest pain-related life-threatening CVDs. The evidence consistently demonstrates that cold weather significantly increases the incidence of such events, often with delayed effects lasting several days to weeks. Vulnerable groups, including the elderly, individuals with chronic conditions, and those of lower socioeconomic status, are particularly at risk. Data also suggest that interventions, including central heating, integrated health warning systems, and appropriate personal protective measures, can effectively mitigate the associated risks. Based on this evidence, the statement provides expert consensus recommendations across clinical, policy, and behavioral domains. Strengthening prevention and response to cold-related cardiovascular risks is essential for building climate-resilient health systems and mitigating the health impacts of climate change.

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Yan M., Sun Q., Yang J., et al. (2026). Cold exposure and acute chest pain-related life-threatening cardiovascular diseases: A scientific statement. The Innovation Medicine 4:100232. https://doi.org/10.59717/j.xinn-med.2026.100232

Yan M., Sun Q., Yang J., et al. (2026). Cold exposure and acute chest pain-related life-threatening cardiovascular diseases: A scientific statement. The Innovation Medicine 4:100232. https://doi.org/10.59717/j.xinn-med.2026.100232

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